Guanine nucleotide-binding regulatory proteins; mediators of transmembrane signaling

Michael P. Graziano, Alfred G. Gilman

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations


Binding of a hormone or neurotransmitter to its cell-surface receptor ultimately modulates the activity of one or more membrane-associated intracellular effectors. Members of a family of guanine nucleotide-binding proteins (G proteins) serve as transducers of receptor-generated signals in several such pathways. Michael Graziano and Alfred Gilman review the functions of both G proteins and the effectors that they regulate. Appreciation of an increasing number of these proteins suggests that they coordinate the cell's response to a wide variety of functionally diverse signals.

Original languageEnglish (US)
Pages (from-to)478-481
Number of pages4
JournalTrends in Pharmacological Sciences
Issue number12
StatePublished - Dec 1987

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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