Abstract
Binding of a hormone or neurotransmitter to its cell-surface receptor ultimately modulates the activity of one or more membrane-associated intracellular effectors. Members of a family of guanine nucleotide-binding proteins (G proteins) serve as transducers of receptor-generated signals in several such pathways. Michael Graziano and Alfred Gilman review the functions of both G proteins and the effectors that they regulate. Appreciation of an increasing number of these proteins suggests that they coordinate the cell's response to a wide variety of functionally diverse signals.
Original language | English (US) |
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Pages (from-to) | 478-481 |
Number of pages | 4 |
Journal | Trends in Pharmacological Sciences |
Volume | 8 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1987 |
ASJC Scopus subject areas
- Toxicology
- Pharmacology