Growth of novel epistatic interactions by gene duplication

Huifeng Jiang, Lin Xu, Zhenglong Gu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Epistasis has long been recognized as fundamentally important in understanding the structure, function, and evolutionary dynamics of biological systems. Gene duplication is a major mechanism of evolution for genetic novelties. Here, we demonstrate that genes evolved significantly more epistatic interactions after duplication. The connectivity of duplicate gene pairs in epistatic networks is positively correlated with the extent of their sequence divergence. Furthermore, duplicate gene pairs tend to epistatically interact with genes that occupy more functional spaces than do single-copy genes. These results show that gene duplication plays an important role in the evolution of epistasis.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalGenome Biology and Evolution
Issue number1
StatePublished - 2011
Externally publishedYes


  • Epistasis
  • Gene duplication
  • Genetic innovation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics


Dive into the research topics of 'Growth of novel epistatic interactions by gene duplication'. Together they form a unique fingerprint.

Cite this