Growth enhancement of transgenic mice expressing human insulin-like growth factor I

L. S. Mathews; Robert E Hammer; R. R. Behringer; A. J. D'Ercole; G. I. Bell; R. L. Brinster; R. D. Palmiter

doi:10.1210/endo-123-6-2827

Growth enhancement of transgenic mice expressing human insulin-like growth factor I

L. S. Mathews, Robert E Hammer, R. R. Behringer, A. J. D'Ercole, G. I. Bell, R. L. Brinster, R. D. Palmiter

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Abstract

A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the normal value. This results in a growth response manifested by a 1.3-fold increase in weight as a result of selective organomegaly without an apparent increase in skeletal growth. In addition, expression of the endogenous GH and IGF-I genes is inhibited. These results are consistent with IGF-I playing an important role in the control of somatic growth.

Original language	English (US)
Pages (from-to)	2827-2833
Number of pages	7
Journal	Endocrinology
Volume	123
Issue number	6
DOIs	https://doi.org/10.1210/endo-123-6-2827
State	Published - Dec 1988

ASJC Scopus subject areas

Endocrinology

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title = "Growth enhancement of transgenic mice expressing human insulin-like growth factor I",

abstract = "A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the normal value. This results in a growth response manifested by a 1.3-fold increase in weight as a result of selective organomegaly without an apparent increase in skeletal growth. In addition, expression of the endogenous GH and IGF-I genes is inhibited. These results are consistent with IGF-I playing an important role in the control of somatic growth.",

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AU - Mathews, L. S.

AU - Hammer, Robert E

AU - Behringer, R. R.

AU - D'Ercole, A. J.

AU - Bell, G. I.

AU - Brinster, R. L.

AU - Palmiter, R. D.

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Growth enhancement of transgenic mice expressing human insulin-like growth factor I

Abstract

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