Growth after implementing a donor breast milk program in neonates <33 weeks gestational age or birthweight <1500 grams: Retrospective cohort study

Mariela Sanchez-Rosado; Cheryl S. Lair; Audrey Edwards; Theresa Jacob; Roy Heyne; L. Steven Brown; Christopher Clark; David B. Nelson; Myra H. Wyckoff; Isabelle Kiefaber; Diksha Verma; Jordan Reis; Patti J. Burchfield; Pollienna Sepulveda; Luc P. Brion

doi:10.1038/s41372-023-01627-2

Growth after implementing a donor breast milk program in neonates <33 weeks gestational age or birthweight <1500 grams: Retrospective cohort study

Mariela Sanchez-Rosado, Cheryl S. Lair, Audrey Edwards, Theresa Jacob, Roy Heyne, L. Steven Brown, Christopher Clark, David B. Nelson, Myra H. Wyckoff, Isabelle Kiefaber, Diksha Verma, Jordan Reis, Patti J. Burchfield, Pollienna Sepulveda, Luc P. Brion

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Donor breast milk (DBM) feeding has been associated with less growth than formula in preterm infants. Zinc content in DBM is insufficient to support growth in preterm infants. Objective: To compare growth from birth to discharge, macro- and micronutrient intake and the frequency of poor growth before (Epoch-1) and after (Epoch-2) implementing a DBM program. Methods: Retrospective cohort study of 1069 infants born at < 33 weeks’ gestational age or birthweight < 1500 g and fed using our adjustable feeding protocol with accurate serial length measurements. Growth was assessed by changes in Z-scores of weight, length and fronto-occipital circumference from birth to discharge. Results: Growth did not decrease significantly in Epoch-2. However, energy and protein intake increased by 5% and frequency of zinc and vitamin D supplementation increased by >30%. Conclusions: DBM implementation did not significantly decrease growth from birth to discharge using our adjustable feeding protocol.

Original language	English (US)
Pages (from-to)	608-615
Number of pages	8
Journal	Journal of Perinatology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1038/s41372-023-01627-2
State	Published - May 2023

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-023-01627-2

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Sanchez-Rosado, M., Lair, C. S., Edwards, A., Jacob, T., Heyne, R., Brown, L. S., Clark, C., Nelson, D. B., Wyckoff, M. H., Kiefaber, I., Verma, D., Reis, J., Burchfield, P. J., Sepulveda, P., & Brion, L. P. (2023). Growth after implementing a donor breast milk program in neonates <33 weeks gestational age or birthweight <1500 grams: Retrospective cohort study. Journal of Perinatology, 43(5), 608-615. https://doi.org/10.1038/s41372-023-01627-2

Sanchez-Rosado, M, Lair, CS, Edwards, A, Jacob, T, Heyne, R, Brown, LS, Clark, C, Nelson, DB , Wyckoff, MH, Kiefaber, I, Verma, D, Reis, J, Burchfield, PJ, Sepulveda, P & Brion, LP 2023, 'Growth after implementing a donor breast milk program in neonates <33 weeks gestational age or birthweight <1500 grams: Retrospective cohort study', Journal of Perinatology, vol. 43, no. 5, pp. 608-615. https://doi.org/10.1038/s41372-023-01627-2

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abstract = "Background: Donor breast milk (DBM) feeding has been associated with less growth than formula in preterm infants. Zinc content in DBM is insufficient to support growth in preterm infants. Objective: To compare growth from birth to discharge, macro- and micronutrient intake and the frequency of poor growth before (Epoch-1) and after (Epoch-2) implementing a DBM program. Methods: Retrospective cohort study of 1069 infants born at < 33 weeks{\textquoteright} gestational age or birthweight < 1500 g and fed using our adjustable feeding protocol with accurate serial length measurements. Growth was assessed by changes in Z-scores of weight, length and fronto-occipital circumference from birth to discharge. Results: Growth did not decrease significantly in Epoch-2. However, energy and protein intake increased by 5% and frequency of zinc and vitamin D supplementation increased by >30%. Conclusions: DBM implementation did not significantly decrease growth from birth to discharge using our adjustable feeding protocol.",

author = "Mariela Sanchez-Rosado and Lair, {Cheryl S.} and Audrey Edwards and Theresa Jacob and Roy Heyne and Brown, {L. Steven} and Christopher Clark and Nelson, {David B.} and Wyckoff, {Myra H.} and Isabelle Kiefaber and Diksha Verma and Jordan Reis and Burchfield, {Patti J.} and Pollienna Sepulveda and Brion, {Luc P.}",

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doi = "10.1038/s41372-023-01627-2",

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T2 - Retrospective cohort study

AU - Sanchez-Rosado, Mariela

AU - Lair, Cheryl S.

AU - Edwards, Audrey

AU - Jacob, Theresa

AU - Heyne, Roy

AU - Brown, L. Steven

AU - Clark, Christopher

AU - Nelson, David B.

AU - Wyckoff, Myra H.

AU - Kiefaber, Isabelle

AU - Verma, Diksha

AU - Reis, Jordan

AU - Burchfield, Patti J.

AU - Sepulveda, Pollienna

AU - Brion, Luc P.

PY - 2023/5

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N2 - Background: Donor breast milk (DBM) feeding has been associated with less growth than formula in preterm infants. Zinc content in DBM is insufficient to support growth in preterm infants. Objective: To compare growth from birth to discharge, macro- and micronutrient intake and the frequency of poor growth before (Epoch-1) and after (Epoch-2) implementing a DBM program. Methods: Retrospective cohort study of 1069 infants born at < 33 weeks’ gestational age or birthweight < 1500 g and fed using our adjustable feeding protocol with accurate serial length measurements. Growth was assessed by changes in Z-scores of weight, length and fronto-occipital circumference from birth to discharge. Results: Growth did not decrease significantly in Epoch-2. However, energy and protein intake increased by 5% and frequency of zinc and vitamin D supplementation increased by >30%. Conclusions: DBM implementation did not significantly decrease growth from birth to discharge using our adjustable feeding protocol.

AB - Background: Donor breast milk (DBM) feeding has been associated with less growth than formula in preterm infants. Zinc content in DBM is insufficient to support growth in preterm infants. Objective: To compare growth from birth to discharge, macro- and micronutrient intake and the frequency of poor growth before (Epoch-1) and after (Epoch-2) implementing a DBM program. Methods: Retrospective cohort study of 1069 infants born at < 33 weeks’ gestational age or birthweight < 1500 g and fed using our adjustable feeding protocol with accurate serial length measurements. Growth was assessed by changes in Z-scores of weight, length and fronto-occipital circumference from birth to discharge. Results: Growth did not decrease significantly in Epoch-2. However, energy and protein intake increased by 5% and frequency of zinc and vitamin D supplementation increased by >30%. Conclusions: DBM implementation did not significantly decrease growth from birth to discharge using our adjustable feeding protocol.

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Growth after implementing a donor breast milk program in neonates <33 weeks gestational age or birthweight <1500 grams: Retrospective cohort study

Abstract

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