TY - JOUR
T1 - Group 1 mGluR-Dependent Synaptic Long-Term Depression
T2 - Mechanisms and Implications for Circuitry and Disease
AU - Lüscher, Christian
AU - Huber, Kimberly M.
N1 - Funding Information:
K.M.H. is supported by grants from the NIH (NS045711, HD052731), Autism Speaks, and Simons Foundation. C.L. is supported by grants from the Swiss National Science Foundation and the Swiss initiative in system biology (SystemsX: neurochoice). K.M.H. is a shareholder and paid SAB member of Seaside Therapeutics. We would like to thank Carlos Gonzalez for assistance with the figures.
PY - 2010/2/25
Y1 - 2010/2/25
N2 - Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the neocortex, hippocampus, midbrain, striatum, and cerebellum. Here we focus on mGluR-induced long-term synaptic depression (LTD) and review the literature that implicates Gp1 mGluRs in the plasticity of behavior, learning, and memory. Moreover, recent studies investigating the molecular mechanisms of mGluR-LTD have discovered links to mental retardation, autism, Alzheimer's disease, Parkinson's disease, and drug addiction. We discuss how mGluRs lead to plasticity of neural circuits and how the understanding of the molecular mechanisms of mGluR plasticity provides insight into brain disease.
AB - Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the neocortex, hippocampus, midbrain, striatum, and cerebellum. Here we focus on mGluR-induced long-term synaptic depression (LTD) and review the literature that implicates Gp1 mGluRs in the plasticity of behavior, learning, and memory. Moreover, recent studies investigating the molecular mechanisms of mGluR-LTD have discovered links to mental retardation, autism, Alzheimer's disease, Parkinson's disease, and drug addiction. We discuss how mGluRs lead to plasticity of neural circuits and how the understanding of the molecular mechanisms of mGluR plasticity provides insight into brain disease.
KW - CELLBIO
KW - MOLNEURO
KW - SIGNALING
UR - http://www.scopus.com/inward/record.url?scp=76849116197&partnerID=8YFLogxK
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U2 - 10.1016/j.neuron.2010.01.016
DO - 10.1016/j.neuron.2010.01.016
M3 - Review article
C2 - 20188650
AN - SCOPUS:76849116197
SN - 0896-6273
VL - 65
SP - 445
EP - 459
JO - Neuron
JF - Neuron
IS - 4
ER -