α,β-Unsaturated dioxolanones derived from mandelic acid smoothly add most Grignard reagents with good to excellent regio- and diastereoselectivities. The adducts are converted to chiral secondary alcohols by peroxidation at low temperature or to protected α-hydroxy aldehydes via ozonolysis.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Feb 26 1996|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry