Graft-vs-Host Disease as a Complication of Lung Transplantation

Douglas M. Smith, Edward D. Agura, Ken Ausloos, W. Steves Ring, Rana Domiati-Saad, Goran B. Klintmalm

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We report a rare case of acute graft-vs-host disease (aGVHD) after a lung transplant. The patient presented with advanced disease manifested by skin rash, fever, diarrhea, liver dysfunction and severe pancytopenia. He went on to die of sepsis and multi-organ failure. aGVHD is a disease often confused with drug reactions or viral infection; therefore, it is important to have a high index of suspicion and to confirm the diagnosis early with tests for donor cell chimerism. Effective treatment is elusive but we are learning a great deal about the underlying mechanisms of this disease and hope to develop better treatment.

Original languageEnglish (US)
Pages (from-to)1175-1177
Number of pages3
JournalJournal of Heart and Lung Transplantation
Issue number9
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation


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