Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles

Christopher L. Paradise; Pooja R. Sarkar; Mina Razzak; Jef K. De Brabander

doi:10.1039/c1ob05390f

Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles

Christopher L. Paradise, Pooja R. Sarkar, Mina Razzak, Jef K. De Brabander

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Amino acid-derived propargylic amides are cyclised in a one-pot, Au(iii)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.

Original language	English (US)
Pages (from-to)	4017-4020
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	11
DOIs	https://doi.org/10.1039/c1ob05390f
State	Published - Jun 7 2011

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles",

abstract = "Amino acid-derived propargylic amides are cyclised in a one-pot, Au(iii)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.",

author = "Paradise, {Christopher L.} and Sarkar, {Pooja R.} and Mina Razzak and {De Brabander}, {Jef K.}",

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AU - Paradise, Christopher L.

AU - Sarkar, Pooja R.

AU - Razzak, Mina

AU - De Brabander, Jef K.

PY - 2011/6/7

Y1 - 2011/6/7

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AB - Amino acid-derived propargylic amides are cyclised in a one-pot, Au(iii)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.

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JO - Organic and Biomolecular Chemistry

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ER -

Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles

Abstract

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