TY - JOUR
T1 - Goal Attainment after Treatment with Abobotulinumtoxina and A Tailored Home Therapy Programme in Children with Upper Limb Spasticity
T2 - Descriptive, Exploratory Analysis of A Large Randomized, Controlled StudyA
AU - Carranza-Del Río, Jorge
AU - Dursun, Nigar
AU - Cekmece, Cigdem
AU - Bonikowski, Marcin
AU - Pyrzanowska, Weronika
AU - Dabrowski, Edward
AU - Tilton, Ann
AU - Oleszek, Joyce
AU - Volteau, Magali
AU - Page, Simon
AU - Shierk, Angela
AU - Delgado, Mauricio R.
PY - 2022/12/9
Y1 - 2022/12/9
N2 - OBJECTIVE: This exploratory analysis of a large, randomized, double-blind study (NCT02106351) describes the effect of treatment with abobotulinumtoxinA followed by a tailored home exercises therapy programme in enabling children with upper limb spasticity due to cerebral palsy to achieve their functional goals using goal attainment scaling (GAS). METHODS: Children with cerebral palsy and spasticity in ≥ 1 upper limb received up to 4 injection cycles of abobotulinumtoxinA (2 U/kg (cycle 1 only), 8U/kg and 16U/kg) into the elbow and wrist flexors and other upper limb muscles selected to support individual treatment goals. Children followed a home exercises therapy programme, which included stretches and exercises specifically chosen to facilitate goal achievement and engagement in activities. RESULTS: For cycle 1, most children had active function goals set as their primary goal (69.7% vs 19.2% passive function goals). GAS T- scores and goal responder rates at week 16 indicated that most types of primary goal were achieved at least as expected during cycle 1 (all groups). Primary goal GAS T-scores were generally maintained for the first 3 abobotulinumtoxinA treatment cycles. CONCLUSION: Most children with upper limb spasticity treated with repeat cycles of abobotulinumtoxinA supported by an individualized home exercises therapy programme achieved their functional goals.
AB - OBJECTIVE: This exploratory analysis of a large, randomized, double-blind study (NCT02106351) describes the effect of treatment with abobotulinumtoxinA followed by a tailored home exercises therapy programme in enabling children with upper limb spasticity due to cerebral palsy to achieve their functional goals using goal attainment scaling (GAS). METHODS: Children with cerebral palsy and spasticity in ≥ 1 upper limb received up to 4 injection cycles of abobotulinumtoxinA (2 U/kg (cycle 1 only), 8U/kg and 16U/kg) into the elbow and wrist flexors and other upper limb muscles selected to support individual treatment goals. Children followed a home exercises therapy programme, which included stretches and exercises specifically chosen to facilitate goal achievement and engagement in activities. RESULTS: For cycle 1, most children had active function goals set as their primary goal (69.7% vs 19.2% passive function goals). GAS T- scores and goal responder rates at week 16 indicated that most types of primary goal were achieved at least as expected during cycle 1 (all groups). Primary goal GAS T-scores were generally maintained for the first 3 abobotulinumtoxinA treatment cycles. CONCLUSION: Most children with upper limb spasticity treated with repeat cycles of abobotulinumtoxinA supported by an individualized home exercises therapy programme achieved their functional goals.
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U2 - 10.2340/jrm.v54.2540
DO - 10.2340/jrm.v54.2540
M3 - Article
C2 - 36306168
AN - SCOPUS:85143917101
SN - 1650-1977
VL - 54
SP - jrm00349
JO - Journal of Rehabilitation Medicine
JF - Journal of Rehabilitation Medicine
ER -