GMFM 1 year after continuous intrathecal baclofen infusion

Linda E. Krach, Robert L. Kriel, Richard C. Gilmartin, Dale M. Swift, Bruce B. Storrs, Rick Abbott, John D. Ward, Karen K. Bloom, William H. Brooks, Joseph R. Madsen, John F. McLaughlin, Joseph M. Nadell

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


The purpose of this study was to assess whether there is an improvement in motor function in persons with cerebral palsy (CP) who have had a reduction of muscle tone by continuous intrathecal baclofen infusion. This was a prospective, open label, non-blinded case series without a control group, conducted at multiple centres. There were 31 subjects, aged 4-29 years. All had a pre-treatment mean lower extremity Ashworth scores of ≥ 3 and a significant reduction in tone after a bolus injection of intrathecal baclofen (ITB) and received an implanted pump for continuous delivery of ITB. Motor function was assessed by the Gross Motor Function Measure (GMFM) prior to and 1 year following pump implantation. Significant improvement (p < 0.05) in mean GMFM scores was seen in subjects < 8 years (mean change 4.1) and in those from 8-18 years (mean change 3.7) and in subjects with CP Classes 2 and 5 (mean changes 6.2 and 2.9). There was a statistically significant decrease (p < 0.05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalPediatric Rehabilitation
Issue number3
StatePublished - Jul 2005


  • Cerebral palsy
  • GMFM
  • Intrathecal baclofen
  • Spasticity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Rehabilitation


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