Glucagon Physiology and Pathophysiology

Roger H Unger

Research output: Contribution to journalReview articlepeer-review

212 Scopus citations


The function of pancreatic glucagon has been questioned for several decades, but it now seems probable that glucagon, like insulin, is extremely important in the moment-to-moment control of the homeostasis of glucose, of certain amino acids and perhaps of free fatty acids. Normal alpha-cell function seems essential to optimal glucoregulation, and abnormal alpha-cell function may cause, contribute to or result from a variety of metabolic disorders, the most common being diabetes mellitus. Biologic Opposition of Glucagon and Insulin Glucagon has been shown to have potent glycogenolytic1 and gluconeogenic2,3 activity at concentrations within the physiologic range. In addition, it may have.

Original languageEnglish (US)
Pages (from-to)443-449
Number of pages7
JournalNew England Journal of Medicine
Issue number8
StatePublished - Aug 19 1971

ASJC Scopus subject areas

  • Medicine(all)


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