Glucagon and Blood Sugar

Keith H. Swenson, Robert N. Alsever, Robert S. Sherwin, Philip Felig, Roger H Unger, Rachmiel Levine

Research output: Contribution to journalLetterpeer-review


To the Editor: Sherwin et al., in their article (N Engl J Med 294: 455–461, 1976), and Levine, in his editorial (N Engl J Med 294: 494–495, 1976), concude that glucagon exerts a diabetogenic action only when there is insulin deficiency and not in the normal patient. This point of view is not consistent with findings in the glucagonoma syndrome, which is a rare clinical condition characterized by the association of a distinctive cutaneous eruption with a glucagon-secreting islet-cell neoplasm of the pancreas. Typically, these patients exhibit a diabetic glucose tolerance curve presumably related to high circulating glucagon levels.

Original languageEnglish (US)
Pages (from-to)1238-1240
Number of pages3
JournalNew England Journal of Medicine
Issue number22
StatePublished - May 27 1976

ASJC Scopus subject areas

  • Medicine(all)


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