GLOMERULONEPHRITIS WITH DEPOSITION OF AUSTRALIA ANTIGEN-ANTIBODY COMPLEXES IN GLOMERULAR BASEMENT MEMBRANE

Burton Combes; James Shorey; Arnaldo Barrera; Peter Stastny; EdwinH Eigenbrodt; AlanR Hull; NormanW Carter

doi:10.1016/S0140-6736(71)92572-4

GLOMERULONEPHRITIS WITH DEPOSITION OF AUSTRALIA ANTIGEN-ANTIBODY COMPLEXES IN GLOMERULAR BASEMENT MEMBRANE

Burton Combes, James Shorey, Arnaldo Barrera, Peter Stastny, EdwinH Eigenbrodt, AlanR Hull, NormanW Carter

Internal Medicine

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

A patient with persistent Australia (Au) antigenæmia after post-transfusion hepatitis developed membranous glomerulonephritis. Immunofluorescent staining of kidney tissue revealed glomerular deposits of IgG, complement C₃, and Au antigen in a pattern characteristic of immune complex deposition. These findings suggest that Au antigen was involved in the formation of immune complexes whose glomerular deposition initiated the pathologic process leading to the development of diffuse membranous glomerulonephritis.

Original language	English (US)
Pages (from-to)	234-237
Number of pages	4
Journal	The Lancet
Volume	298
Issue number	7718
DOIs	https://doi.org/10.1016/S0140-6736(71)92572-4
State	Published - Jul 31 1971

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(71)92572-4

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title = "GLOMERULONEPHRITIS WITH DEPOSITION OF AUSTRALIA ANTIGEN-ANTIBODY COMPLEXES IN GLOMERULAR BASEMENT MEMBRANE",

abstract = "A patient with persistent Australia (Au) antigen{\ae}mia after post-transfusion hepatitis developed membranous glomerulonephritis. Immunofluorescent staining of kidney tissue revealed glomerular deposits of IgG, complement C3, and Au antigen in a pattern characteristic of immune complex deposition. These findings suggest that Au antigen was involved in the formation of immune complexes whose glomerular deposition initiated the pathologic process leading to the development of diffuse membranous glomerulonephritis.",

author = "Burton Combes and James Shorey and Arnaldo Barrera and Peter Stastny and EdwinH Eigenbrodt and AlanR Hull and NormanW Carter",

note = "Funding Information: This work was supported in part by U.S. Public Health Service grants 5 R01-AM 13757, and 2 T01-AM 5490. B. C. is a recipient of U.S.P.H.S. research career award 5 K03 AM 18260. We thank Dr. Billy Oliver for referring this patient to",

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doi = "10.1016/S0140-6736(71)92572-4",

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AU - Shorey, James

AU - Barrera, Arnaldo

AU - Stastny, Peter

AU - Eigenbrodt, EdwinH

AU - Hull, AlanR

AU - Carter, NormanW

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N2 - A patient with persistent Australia (Au) antigenæmia after post-transfusion hepatitis developed membranous glomerulonephritis. Immunofluorescent staining of kidney tissue revealed glomerular deposits of IgG, complement C3, and Au antigen in a pattern characteristic of immune complex deposition. These findings suggest that Au antigen was involved in the formation of immune complexes whose glomerular deposition initiated the pathologic process leading to the development of diffuse membranous glomerulonephritis.

AB - A patient with persistent Australia (Au) antigenæmia after post-transfusion hepatitis developed membranous glomerulonephritis. Immunofluorescent staining of kidney tissue revealed glomerular deposits of IgG, complement C3, and Au antigen in a pattern characteristic of immune complex deposition. These findings suggest that Au antigen was involved in the formation of immune complexes whose glomerular deposition initiated the pathologic process leading to the development of diffuse membranous glomerulonephritis.

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GLOMERULONEPHRITIS WITH DEPOSITION OF AUSTRALIA ANTIGEN-ANTIBODY COMPLEXES IN GLOMERULAR BASEMENT MEMBRANE

Abstract

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