Genomic and Clinicopathological Characterization of CRLF2-Rearranged Mixed Phenotype Acute Leukemia

Lina Han; Ruifang Zheng; Franklin Fuda; Miguel D. Cantu; Prasad Koduru; Jesse M. Jaso; Olga Weinberg; Sharon Germans; Mingyi Chen; Jing Xu; Weina Chen

doi:10.1002/pbc.31507

Genomic and Clinicopathological Characterization of CRLF2-Rearranged Mixed Phenotype Acute Leukemia

Lina Han, Ruifang Zheng, Franklin Fuda, Miguel D. Cantu, Prasad Koduru, Jesse M. Jaso, Olga Weinberg, Sharon Germans, Mingyi Chen, Jing Xu, Weina Chen

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Rearrangements of cytokine receptor-like factor 2 gene (CRLF2) are present in ∼50% of B-lymphoblastic leukemia/lymphoma (B-ALL) with BCR::ABL1-like features. Herein, we report three patients with CRLF2-rearranged mixed phenotype acute leukemia (MPAL). All three cases were B/myeloid MPAL in young patients harboring P2RY8::CRLF2 or IGH::CRLF2 with additional genomic alterations in signaling (JAK and RAS) and cell cycle (CDKN2A/B) pathways, a genomic profile similar to that in BCR::ABL1-like B-ALL. Our study is the first case series to demonstrate clinicopathological and genomic features of this underrecognized entity. We recommend upfront genetic/molecular testing to timely diagnose and further characterize MPAL with BCR::ABL1-like features.

Original language	English (US)
Article number	e31507
Journal	Pediatric Blood and Cancer
Volume	72
Issue number	3
DOIs	https://doi.org/10.1002/pbc.31507
State	Published - Mar 2025

Keywords

B lymphoblastic leukemia
BCR::ABL1-like
CRLF2
mixed phenotype acute leukemia

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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title = "Genomic and Clinicopathological Characterization of CRLF2-Rearranged Mixed Phenotype Acute Leukemia",

abstract = "Rearrangements of cytokine receptor-like factor 2 gene (CRLF2) are present in ∼50% of B-lymphoblastic leukemia/lymphoma (B-ALL) with BCR::ABL1-like features. Herein, we report three patients with CRLF2-rearranged mixed phenotype acute leukemia (MPAL). All three cases were B/myeloid MPAL in young patients harboring P2RY8::CRLF2 or IGH::CRLF2 with additional genomic alterations in signaling (JAK and RAS) and cell cycle (CDKN2A/B) pathways, a genomic profile similar to that in BCR::ABL1-like B-ALL. Our study is the first case series to demonstrate clinicopathological and genomic features of this underrecognized entity. We recommend upfront genetic/molecular testing to timely diagnose and further characterize MPAL with BCR::ABL1-like features.",

keywords = "B lymphoblastic leukemia, BCR::ABL1-like, CRLF2, mixed phenotype acute leukemia",

author = "Lina Han and Ruifang Zheng and Franklin Fuda and Cantu, {Miguel D.} and Prasad Koduru and Jaso, {Jesse M.} and Olga Weinberg and Sharon Germans and Mingyi Chen and Jing Xu and Weina Chen",

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doi = "10.1002/pbc.31507",

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AU - Han, Lina

AU - Zheng, Ruifang

AU - Fuda, Franklin

AU - Cantu, Miguel D.

AU - Koduru, Prasad

AU - Jaso, Jesse M.

AU - Weinberg, Olga

AU - Germans, Sharon

AU - Chen, Mingyi

AU - Xu, Jing

AU - Chen, Weina

PY - 2025/3

Y1 - 2025/3

N2 - Rearrangements of cytokine receptor-like factor 2 gene (CRLF2) are present in ∼50% of B-lymphoblastic leukemia/lymphoma (B-ALL) with BCR::ABL1-like features. Herein, we report three patients with CRLF2-rearranged mixed phenotype acute leukemia (MPAL). All three cases were B/myeloid MPAL in young patients harboring P2RY8::CRLF2 or IGH::CRLF2 with additional genomic alterations in signaling (JAK and RAS) and cell cycle (CDKN2A/B) pathways, a genomic profile similar to that in BCR::ABL1-like B-ALL. Our study is the first case series to demonstrate clinicopathological and genomic features of this underrecognized entity. We recommend upfront genetic/molecular testing to timely diagnose and further characterize MPAL with BCR::ABL1-like features.

AB - Rearrangements of cytokine receptor-like factor 2 gene (CRLF2) are present in ∼50% of B-lymphoblastic leukemia/lymphoma (B-ALL) with BCR::ABL1-like features. Herein, we report three patients with CRLF2-rearranged mixed phenotype acute leukemia (MPAL). All three cases were B/myeloid MPAL in young patients harboring P2RY8::CRLF2 or IGH::CRLF2 with additional genomic alterations in signaling (JAK and RAS) and cell cycle (CDKN2A/B) pathways, a genomic profile similar to that in BCR::ABL1-like B-ALL. Our study is the first case series to demonstrate clinicopathological and genomic features of this underrecognized entity. We recommend upfront genetic/molecular testing to timely diagnose and further characterize MPAL with BCR::ABL1-like features.

KW - B lymphoblastic leukemia

KW - BCR::ABL1-like

KW - CRLF2

KW - mixed phenotype acute leukemia

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Genomic and Clinicopathological Characterization of CRLF2-Rearranged Mixed Phenotype Acute Leukemia

Abstract

Keywords

ASJC Scopus subject areas

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