@article{d248a653f55b4244830bfbfb0c16f046,
title = "Genetic variation at IFNL4 influences extrahepatic interferon-stimulated gene expression in chronic HCV patients",
abstract = "Polymorphisms at IFNL4 strongly influence spontaneous resolution and interferon therapeutic response in hepatitis C virus (HCV) infection. In chronic HCV, unfavorable alleles are associated with elevated interferon (IFN)-stimulated gene (ISG) expression in the liver, but extrahepatic effects are less well characterized. We used RNA sequencing (RNA-Seq) to examine whether IFNL4 genetic variation (rs368234815) modulates ISG expression in peripheral blood mononuclear cells (PBMC) during chronic HCV infection. ISG expression was elevated in unstimulated PBMC homozygous for the unfavorable δG IFNL4 variant; expression following IFN-α stimulation was comparable across genotypes. These findings suggest that lambda interferons may have broader systemic effects during HCV infection.",
keywords = "Hepatitis C, IFNL4, Interferon, Interferon-stimulated genes, Peripheral blood mononuclear cells",
author = "Rosenberg, {Brad R.} and Freije, {Catherine A.} and Naoko Imanaka and Chen, {Spencer T.} and Eitson, {Jennifer L.} and Rachel Caron and Uhl, {Skyler A.} and Marija Zeremski and Andrew Talal and Jacobson, {Ira M.} and Rice, {Charles M.} and Schoggins, {John W.}",
note = "Funding Information: Financial support. This work was supported in part by the National Institutes of Health (grant numbers DK095031 to J. W. S., AI091707 to C. M. R., AI111825 to B. R. R. and C. M. R.); the John C. Whitehead Presidential Fellowship to B. R. R.; the American Cancer Society Institutional Research Grant (grant number 02-196 to UT Soutwestern Medical Center); The Rockefeller University Center for Clinical and Translational Science Award (grant number UL1RR024143); and by the Center for Basic and Translational Research on Disorders of the Digestive System through the generosity of the Leona M. and Harry B. Helmsley Charitable Trust. Additional funding was provided by the Greenberg Medical Research Institute, the Starr Foundation, the Ronald A. Shellow, M.D. Memorial Fund Publisher Copyright: {\textcopyright} The Author(s) 2017.",
year = "2018",
month = feb,
day = "15",
doi = "10.1093/infdis/jix593",
language = "English (US)",
volume = "217",
pages = "650--655",
journal = "The Journal of infectious diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",
}