Genetic nomenclature for chicken immunoglobulin allotypes: An extensive survey of inbred lines and antisera

James M. Foppoli; Lean Kuan Ch'ng; Albert A. Benedict; Juraj Ivanyi; Josef Derka; Edward K. Wakeland

doi:10.1007/BF01561451

Genetic nomenclature for chicken immunoglobulin allotypes: An extensive survey of inbred lines and antisera

James M. Foppoli, Lean Kuan Ch'ng, Albert A. Benedict, Juraj Ivanyi, Josef Derka, Edward K. Wakeland

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Abstract

Based on a survey of 36 inbred and 8 partially inbred chicken lines and outbred jungle fowl, and with 29 alloantisera generated in different laboratories, 13 7S Ig and 5 IgM allotypes were designated and a new system of nomenclature for chicken Ig polymorphisms was developed. The survey also revealed considerable genetic polymorphism in the structural gene(s) (G-1) responsible for the production of 7S Ig H chains. IgM H chains, encoded by the M-1 locus were less polymorphic. Nine G-1 and four M-1 gene alleles were delineated in highly inbred lines by the formation of unique combinations of G-1 or M-1 specificities. Five additional G-1 alleles were found in chicken lines and jungle fowl segregating for allotypes. Thirty-three percent of the G-1:M-1 haplotypes theoretically expected, were detected in inbred lines.

Original language	English (US)
Pages (from-to)	385-404
Number of pages	20
Journal	Immunogenetics
Volume	8
Issue number	1
DOIs	https://doi.org/10.1007/BF01561451
State	Published - Dec 1979

ASJC Scopus subject areas

Immunology
Genetics

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10.1007/BF01561451

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title = "Genetic nomenclature for chicken immunoglobulin allotypes: An extensive survey of inbred lines and antisera",

abstract = "Based on a survey of 36 inbred and 8 partially inbred chicken lines and outbred jungle fowl, and with 29 alloantisera generated in different laboratories, 13 7S Ig and 5 IgM allotypes were designated and a new system of nomenclature for chicken Ig polymorphisms was developed. The survey also revealed considerable genetic polymorphism in the structural gene(s) (G-1) responsible for the production of 7S Ig H chains. IgM H chains, encoded by the M-1 locus were less polymorphic. Nine G-1 and four M-1 gene alleles were delineated in highly inbred lines by the formation of unique combinations of G-1 or M-1 specificities. Five additional G-1 alleles were found in chicken lines and jungle fowl segregating for allotypes. Thirty-three percent of the G-1:M-1 haplotypes theoretically expected, were detected in inbred lines.",

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T2 - An extensive survey of inbred lines and antisera

AU - Foppoli, James M.

AU - Ch'ng, Lean Kuan

AU - Benedict, Albert A.

AU - Ivanyi, Juraj

AU - Derka, Josef

AU - Wakeland, Edward K.

PY - 1979/12

Y1 - 1979/12

N2 - Based on a survey of 36 inbred and 8 partially inbred chicken lines and outbred jungle fowl, and with 29 alloantisera generated in different laboratories, 13 7S Ig and 5 IgM allotypes were designated and a new system of nomenclature for chicken Ig polymorphisms was developed. The survey also revealed considerable genetic polymorphism in the structural gene(s) (G-1) responsible for the production of 7S Ig H chains. IgM H chains, encoded by the M-1 locus were less polymorphic. Nine G-1 and four M-1 gene alleles were delineated in highly inbred lines by the formation of unique combinations of G-1 or M-1 specificities. Five additional G-1 alleles were found in chicken lines and jungle fowl segregating for allotypes. Thirty-three percent of the G-1:M-1 haplotypes theoretically expected, were detected in inbred lines.

AB - Based on a survey of 36 inbred and 8 partially inbred chicken lines and outbred jungle fowl, and with 29 alloantisera generated in different laboratories, 13 7S Ig and 5 IgM allotypes were designated and a new system of nomenclature for chicken Ig polymorphisms was developed. The survey also revealed considerable genetic polymorphism in the structural gene(s) (G-1) responsible for the production of 7S Ig H chains. IgM H chains, encoded by the M-1 locus were less polymorphic. Nine G-1 and four M-1 gene alleles were delineated in highly inbred lines by the formation of unique combinations of G-1 or M-1 specificities. Five additional G-1 alleles were found in chicken lines and jungle fowl segregating for allotypes. Thirty-three percent of the G-1:M-1 haplotypes theoretically expected, were detected in inbred lines.

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Genetic nomenclature for chicken immunoglobulin allotypes: An extensive survey of inbred lines and antisera

Abstract

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