Genetic dissection of systemic lupus erythematosus

Edward K. Wakeland; Amy E. Wandstrat; Kui Liu; Laurence Morel

doi:10.1016/S0952-7915(99)00039-4

Genetic dissection of systemic lupus erythematosus

Edward K. Wakeland, Amy E. Wandstrat, Kui Liu, Laurence Morel

Research output: Contribution to journal › Review article › peer-review

136 Scopus citations

Abstract

Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in three separate pathways contribute to the initiation and progression of systemic autoimmunity. Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans.

Original language	English (US)
Pages (from-to)	701-707
Number of pages	7
Journal	Current Opinion in Immunology
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/S0952-7915(99)00039-4
State	Published - Dec 1 1999

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Genetic dissection of systemic lupus erythematosus",

abstract = "Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in three separate pathways contribute to the initiation and progression of systemic autoimmunity. Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans.",

author = "Wakeland, {Edward K.} and Wandstrat, {Amy E.} and Kui Liu and Laurence Morel",

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AU - Wakeland, Edward K.

AU - Wandstrat, Amy E.

AU - Liu, Kui

AU - Morel, Laurence

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Y1 - 1999/12/1

N2 - Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in three separate pathways contribute to the initiation and progression of systemic autoimmunity. Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans.

AB - Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in three separate pathways contribute to the initiation and progression of systemic autoimmunity. Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans.

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Genetic dissection of systemic lupus erythematosus

Abstract

ASJC Scopus subject areas

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