Genetic brain malformations recapitulate phylogeny.

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4 Scopus citations


It is generally difficult to establish whether a congenital brain malformation has a genetic basis or is due to other factors. A thesis has been developed, that brain malformations with a genetic basis recapitulate phylogeny. In order to validate this thesis a retrospective CT investigation of brain dysmorphology was carried out in 50 cases of dysgenesis of the corpus callosum, 20 cases of the holoprosencephaly complex, 25 cases of Dandy-Walker malformation, and 50 cases of miscellaneous brain anomalies. This group was compared with 100 neonates with brain damage from acquired causes. The results strongly suggest that a brain malformation that recapitulates phylogeny is very likely to be based on genetic aberration.

Original languageEnglish (US)
Pages (from-to)637-641
Number of pages5
JournalActa radiologica. Supplementum
StatePublished - 1986

ASJC Scopus subject areas

  • Medicine(all)


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