Abstract
It is generally difficult to establish whether a congenital brain malformation has a genetic basis or is due to other factors. A thesis has been developed, that brain malformations with a genetic basis recapitulate phylogeny. In order to validate this thesis a retrospective CT investigation of brain dysmorphology was carried out in 50 cases of dysgenesis of the corpus callosum, 20 cases of the holoprosencephaly complex, 25 cases of Dandy-Walker malformation, and 50 cases of miscellaneous brain anomalies. This group was compared with 100 neonates with brain damage from acquired causes. The results strongly suggest that a brain malformation that recapitulates phylogeny is very likely to be based on genetic aberration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 637-641 |
| Number of pages | 5 |
| Journal | Acta radiologica. Supplementum |
| Volume | 369 |
| State | Published - 1986 |
ASJC Scopus subject areas
- General Medicine