Abstract
Genetic abnormalities may account for 15-30% of male factor infertility. Genes and genomic regulation involved in male genital tract development, gonadal development, and function including those related to spermatogenesis may be involved with male infertility. Although many of the genetic factors are still to be elucidated and many of the predicted genetic perturbations are yet to find their place for clinical applications, it is essential to appraise the current information on genetic basis of male reproductive system disorders.
Original language | English (US) |
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Title of host publication | Male Infertility |
Subtitle of host publication | Contemporary Clinical Approaches, Andrology, ART and Antioxidants |
Publisher | Springer New York |
Pages | 171-189 |
Number of pages | 19 |
ISBN (Electronic) | 9781461433354 |
ISBN (Print) | 9781461433347 |
DOIs | |
State | Published - Jan 1 2012 |
Keywords
- Genetics in male infertility
- Genomic regulation of male sexual development
- Hypospadias
- Male genital tract development
- Peritubular myoid cells
- Sertoli cells
- Spermatogenesis
- Spermatogenic genes
- Testis formation
ASJC Scopus subject areas
- General Medicine