TY - JOUR
T1 - Genetic and Cellular Contributions to Liver Regeneration
AU - Liang, Roger
AU - Lin, Yu Hsuan
AU - Zhu, Hao
N1 - Funding Information:
We thank P. Mishra and Austin Moore for constructive feedback on the manuscript. We thank Adam Yopp for the MRI images in Figure 2A. Y.-H.L. was supported by the Moody Foundation. H.Z. was supported by NCI R01 CA251928 and NIDDK R01 DK125396.
Publisher Copyright:
© 2022 Cold Spring Harbor Laboratory Press; all rights reserved;.
PY - 2022/9
Y1 - 2022/9
N2 - The regenerative capabilities of the liver represent a paradigm for understanding tissue repair in solid organs. Regeneration after partial hepatectomy in rodent models is well understood, while regeneration in the context of clinically relevant chronic injuries is less studied. Given the growing incidence of fatty liver disease, cirrhosis, and liver cancer, interest in liver regeneration is increasing. Here, we will review the principles, genetics, and cell biology underlying liver regeneration, as well as new approaches being used to study heterogeneity in liver tissue maintenance and repair.
AB - The regenerative capabilities of the liver represent a paradigm for understanding tissue repair in solid organs. Regeneration after partial hepatectomy in rodent models is well understood, while regeneration in the context of clinically relevant chronic injuries is less studied. Given the growing incidence of fatty liver disease, cirrhosis, and liver cancer, interest in liver regeneration is increasing. Here, we will review the principles, genetics, and cell biology underlying liver regeneration, as well as new approaches being used to study heterogeneity in liver tissue maintenance and repair.
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U2 - 10.1101/cshperspect.a040832
DO - 10.1101/cshperspect.a040832
M3 - Article
C2 - 34750173
AN - SCOPUS:85125244623
SN - 1943-0264
VL - 14
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
IS - 9
M1 - a040832
ER -