Abstract
The Drosophila fat facets gene encodes a deubiquitinating enzyme required during eye development to limit the number of photoreceptors in each facet to eight. Ubiquitin is a small polypeptide that targets proteins for degradation by the proteasome. Deubiquitinating enzymes cleave ubiquitin- protein bonds. In order to investigate the role of FAT FACETS in the ubiquitin pathway, genetic interactions between fat facets and the Drosophila UbcD 1 gene were assessed. In addition, three yeast deubiquitinating enzyme genes were tested for their ability to substitute for fat facets in the developing Drosophila eye and for their effects on eye morphology. The results of these experiments support the hypothesis that FAT FACETS activity antagonizes that of the proteolytic machinery. The implications of these results for the specificity of FAF and yeast UBPs are discussed as well.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 312-320 |
| Number of pages | 9 |
| Journal | Developmental Genetics |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1999 |
Keywords
- Deubiquitinating enzyme
- Drosophila
- Eye development
- Fat facets
- UBP
- Ubiquitin
ASJC Scopus subject areas
- Genetics
- Developmental Biology
- Cell Biology