@article{35a8f59d2a0440b4890b4dc0f819a353,
title = "Genetic analysis of the circadian system of mammals: properties and prospects",
abstract = "Two autosomal semidominant mutations that affect the period of the circadian clock have been discovered in rodents. In the golden hamster, the tau mutation shortens the period from 24 h (wild-type) to 22 h (heterozygote) and 20 h (homozygote). In the mouse the Clock mutation lengthens the period by more than 1 h (heterozygote) and initially by about 4 h in homozygotes, which then become arrhythmic within 3 weeks. These mutations, and the others that will surely be identified by further screening, will provide powerful tools for the dissection of the mammalian clock at both the molecular and the system level.",
keywords = "circadian, clock, hamster, mouse, mutation",
author = "Michael Menaker and Takahashi, {Joseph S.}",
note = "Funding Information: tions. We thank our many colleagues who encouraged, supported and contributed to the ideas and work discussed here. Research was supported by NIH grant ROl HD 13162 and AFOSR grant F49620-93-l-0185 to M.M.; NIH grants R37 MH 39592, ROl MH 49241, ROl EY 08467 and a grant from the MacArthur Foundation Network on Depression to J.S.T; a State bf Illinois HECA award to J.S.T., EW. Turek, L.H. Pinto; and by the NSF Center for Biological Timing the University of Virginia for M.M. and J.S.T. Funding Information: Figure 4. Rate-temperature relationships in isolated perfused hearts of homozygous tau mutant (0) and wild-type hamsters (a). Hearts were removed from the animals and perfused through the aorta with modifications of the technique described in ref 19. The curves are best fit to the data; solid line to the mutant data, dotted line to the wild-type data. Experiments were performed by Ramin Ipakchi and Shin Yu with support from a Howard Hughes Medical Institute undergraduate award.",
year = "1995",
month = feb,
doi = "10.1016/1044-5765(95)90018-7",
language = "English (US)",
volume = "7",
pages = "61--70",
journal = "Seminars in Neuroscience",
issn = "1044-5765",
publisher = "Academic Press Inc.",
number = "1",
}