@inbook{c4134d4a8e2543cebd2381120575611b,
title = "Generation of ultra-small PLGA nanoparticles by sequential centrifugation",
abstract = "Direct, local delivery of polymer nanoparticles to the brain is a promising strategy to bypass the blood-brain barrier (BBB) and safely deliver a large therapeutic payload. However, even with the aid of convection-enhanced delivery (CED) techniques, this approach has been limited by the inability to fabricate appropriately sized polymer nanoparticles. Here, we outline a versatile and efficient method for producing polymer nanoparticles that are <100 nm in diameter and can be delivered to the brain via CED.",
keywords = "Blood-brain barrier, Brain, Convection-enhanced delivery, Nanoparticle, PLGA, Polymer",
author = "Xingwang Wu and Jiangbing Zhou and Patel, {Toral R.}",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2018.",
year = "2018",
doi = "10.1007/978-1-4939-8661-3_2",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "17--24",
booktitle = "Methods in Molecular Biology",
}