Abstract
Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme).
Original language | English (US) |
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Pages (from-to) | 15836-15840 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 19 |
Issue number | 47 |
DOIs | |
State | Published - Nov 18 2013 |
Externally published | Yes |
Keywords
- C-H activation
- benzocoumarins
- carboxylic acids
- oxygenation
- radical reactions
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry