Gastrin‐secreting tumor of the duodenum (G‐cell apudoma) associated with secondary biliary cirrhosis

W. M. Lee, F. Silva, J. B. Price

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A middle‐aged woman with evidence of chronic cholestasis of several years and no previous abdominal surgery was initially thought to have primary biliary cirrhosis. Clinical evaluation disclosed a well‐developed secondary biliary cirrhosis apparently caused by extrahepatic obstruction due to a 1 × 2 cm neoplasm of the periampullary duodenum. Electron microscopy and immunofluorescent studies showed the neoplasm to be a G‐cell adenoma. Wide local excision has resolved the biliary obstruction. Benign or slow‐growing duodenal tumors, if they involve the ampulla of Vater, may produce prolonged partial extrahepatic obstruction and secondary biliary cirrhosis.

Original languageEnglish (US)
Pages (from-to)2596-2601
Number of pages6
Issue number12
StatePublished - Jun 15 1982

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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