Gastric Cancer as Preventable Disease

Massimo Rugge, Robert M. Genta, Francesco Di Mario, Emad M. El-Omar, Hashem B. El-Serag, Matteo Fassan, Richard H. Hunt, Ernst J. Kuipers, Peter Malfertheiner, Kentaro Sugano, David Y. Graham

Research output: Contribution to journalArticlepeer-review

138 Scopus citations


Gastric cancer, 1 of the 5 most common causes of cancer death, is associated with a 5-year overall survival rate less than 30%. A minority of cancers occurs as part of syndromic diseases; more than 90% of adenocarcinomas are considered as the ultimate consequence of a longstanding mucosal inflammation. Helicobacter pylori infection is the leading etiology of non–self-limiting gastritis, which may result in atrophy of the gastric mucosa and impaired acid secretion. Gastric atrophy establishes a field of cancerization prone to further molecular and phenotypic changes, possibly resulting in cancer growth. This well-understood natural history provides the clinicopathologic rationale for primary and secondary cancer prevention strategies. A large body of evidence demonstrates that combined primary (H pylori eradication) and secondary (mainly endoscopy) prevention efforts may prevent or limit the progression of gastric oncogenesis. This approach, which is tailored to different country-specific gastric cancer incidence, socioeconomic, and cultural factors, requires that the complementary competences of gastroenterologists, oncologists, and pathologists be amalgamated into a common strategy of health policy.

Original languageEnglish (US)
Pages (from-to)1833-1843
Number of pages11
JournalClinical Gastroenterology and Hepatology
Issue number12
StatePublished - Dec 2017


  • Gastric Cancer
  • Gastritis
  • Helicobacter pylori
  • Primary Prevention
  • Secondary Prevention

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Gastric Cancer as Preventable Disease'. Together they form a unique fingerprint.

Cite this