TY - CHAP
T1 - Gastric A cell function in normal dogs
AU - Munoz Barragan, L.
AU - Blazquez, E.
AU - Patton, G. S.
AU - Muñoz-Barragan, L.
AU - Dobbs, R. E.
AU - Unger, Roger H
PY - 1976
Y1 - 1976
N2 - Glucagon release from the gastric fundus and pancreas were compared in normal dogs by measuring glucagon in plasma from a major gastroepiploic vein, the superior pancreaticoduodenal vein, and the inferior vene cava. In 32 dogs in the basal state, gastric vein glucagon averaged 97 ± 40 pg/ml, not significantly different from the 93 ± 41 pg/ml level in the vena cava. Pancreaticoduodenal vein glucagon averaged 250 ± 32 pg/ml (P <0.001). Intravenous arginine infused in four dogs caused a rise in mean gastric vein glucagon to 210 ± 33 pg/ml within 3 min. and glucagon remained between 53 and 98 pg/ml above the vena caval level thereafter. In the gastric vein, the rise in glucagon was significantly greater than in the vena cava at 3,5, and 10 min (P<0.05), but was far less than in the pancreaticoduodenal vein where glucagon rose to 1,295 ± 379 pg/ml at 1.5 min. Evidence of modest gastric glucagon release was observed after the intragastric instillation of arginine,,but not during insulin or phloridzin induced hypoglycemia. It was concluded that in normal dogs under the circumstances studied, the gastric fundus is not a major source of circulating glucagon.
AB - Glucagon release from the gastric fundus and pancreas were compared in normal dogs by measuring glucagon in plasma from a major gastroepiploic vein, the superior pancreaticoduodenal vein, and the inferior vene cava. In 32 dogs in the basal state, gastric vein glucagon averaged 97 ± 40 pg/ml, not significantly different from the 93 ± 41 pg/ml level in the vena cava. Pancreaticoduodenal vein glucagon averaged 250 ± 32 pg/ml (P <0.001). Intravenous arginine infused in four dogs caused a rise in mean gastric vein glucagon to 210 ± 33 pg/ml within 3 min. and glucagon remained between 53 and 98 pg/ml above the vena caval level thereafter. In the gastric vein, the rise in glucagon was significantly greater than in the vena cava at 3,5, and 10 min (P<0.05), but was far less than in the pancreaticoduodenal vein where glucagon rose to 1,295 ± 379 pg/ml at 1.5 min. Evidence of modest gastric glucagon release was observed after the intragastric instillation of arginine,,but not during insulin or phloridzin induced hypoglycemia. It was concluded that in normal dogs under the circumstances studied, the gastric fundus is not a major source of circulating glucagon.
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M3 - Chapter
C2 - 984193
AN - SCOPUS:0017133188
VL - 231
SP - 1057
EP - 1061
BT - American Journal of Physiology
ER -