Gamma knife stereotactic radiosurgery for low-grade astrocytomas

Mark A. Henderson; Achilles J. Fakiris; Robert D. Timmerman; Robert M. Worth; Simon S. Lo; Thomas C. Witt

doi:10.1159/000209297

Gamma knife stereotactic radiosurgery for low-grade astrocytomas

Mark A. Henderson, Achilles J. Fakiris, Robert D. Timmerman, Robert M. Worth, Simon S. Lo, Thomas C. Witt

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Patients with low-grade astrocytoma (LGA; 8 pilocytic astrocytomas, 2 subependymal giant cell astrocytomas, 2 fibrillary astrocytomas) were selected for treatment with gamma knife stereotactic radiosurgery (GKSRS) based on having a demarcated appearance on CT or MRI and the possibility of dose sparing of adjacent eloquent structures. A median dose of 13 Gy was prescribed to the 50% isodose line, which covered the gross tumor. The median patient age was 17.4 years. The median target volume was 4.4 cm³. With a median follow-up of 48.2 months, 4-year tumor control and overall survival were 77 and 83%, respectively. Only 2 patients experienced symptomatic treatment-related toxicity. GKSRS can provide local control in cases of unresectable or recurrent LGA with a low incidence of side effects in carefully selected patients.

Original language	English (US)
Pages (from-to)	161-167
Number of pages	7
Journal	Stereotactic and Functional Neurosurgery
Volume	87
Issue number	3
DOIs	https://doi.org/10.1159/000209297
State	Published - Jun 2009

Keywords

Astrocytoma, low grade
Gamma knife
Glioma
Radiosurgery

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1159/000209297

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title = "Gamma knife stereotactic radiosurgery for low-grade astrocytomas",

abstract = "Patients with low-grade astrocytoma (LGA; 8 pilocytic astrocytomas, 2 subependymal giant cell astrocytomas, 2 fibrillary astrocytomas) were selected for treatment with gamma knife stereotactic radiosurgery (GKSRS) based on having a demarcated appearance on CT or MRI and the possibility of dose sparing of adjacent eloquent structures. A median dose of 13 Gy was prescribed to the 50% isodose line, which covered the gross tumor. The median patient age was 17.4 years. The median target volume was 4.4 cm3. With a median follow-up of 48.2 months, 4-year tumor control and overall survival were 77 and 83%, respectively. Only 2 patients experienced symptomatic treatment-related toxicity. GKSRS can provide local control in cases of unresectable or recurrent LGA with a low incidence of side effects in carefully selected patients.",

keywords = "Astrocytoma, low grade, Gamma knife, Glioma, Radiosurgery",

author = "Henderson, {Mark A.} and Fakiris, {Achilles J.} and Timmerman, {Robert D.} and Worth, {Robert M.} and Lo, {Simon S.} and Witt, {Thomas C.}",

year = "2009",

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doi = "10.1159/000209297",

language = "English (US)",

volume = "87",

pages = "161--167",

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AU - Henderson, Mark A.

AU - Fakiris, Achilles J.

AU - Timmerman, Robert D.

AU - Worth, Robert M.

AU - Lo, Simon S.

AU - Witt, Thomas C.

PY - 2009/6

Y1 - 2009/6

N2 - Patients with low-grade astrocytoma (LGA; 8 pilocytic astrocytomas, 2 subependymal giant cell astrocytomas, 2 fibrillary astrocytomas) were selected for treatment with gamma knife stereotactic radiosurgery (GKSRS) based on having a demarcated appearance on CT or MRI and the possibility of dose sparing of adjacent eloquent structures. A median dose of 13 Gy was prescribed to the 50% isodose line, which covered the gross tumor. The median patient age was 17.4 years. The median target volume was 4.4 cm3. With a median follow-up of 48.2 months, 4-year tumor control and overall survival were 77 and 83%, respectively. Only 2 patients experienced symptomatic treatment-related toxicity. GKSRS can provide local control in cases of unresectable or recurrent LGA with a low incidence of side effects in carefully selected patients.

AB - Patients with low-grade astrocytoma (LGA; 8 pilocytic astrocytomas, 2 subependymal giant cell astrocytomas, 2 fibrillary astrocytomas) were selected for treatment with gamma knife stereotactic radiosurgery (GKSRS) based on having a demarcated appearance on CT or MRI and the possibility of dose sparing of adjacent eloquent structures. A median dose of 13 Gy was prescribed to the 50% isodose line, which covered the gross tumor. The median patient age was 17.4 years. The median target volume was 4.4 cm3. With a median follow-up of 48.2 months, 4-year tumor control and overall survival were 77 and 83%, respectively. Only 2 patients experienced symptomatic treatment-related toxicity. GKSRS can provide local control in cases of unresectable or recurrent LGA with a low incidence of side effects in carefully selected patients.

KW - Astrocytoma, low grade

KW - Gamma knife

KW - Glioma

KW - Radiosurgery

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Gamma knife stereotactic radiosurgery for low-grade astrocytomas

Abstract

Keywords

ASJC Scopus subject areas

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