Gamma glutamy1 transpeptidase in normal pregnancy

F. B. Walker, D. L. Hoblit, F. G. Cunningham, B. Combes

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Scrum activity of gamma glutamyl transpepti-dase (GGT) was measured throughout normal gestation. The GGT values during pregnancy, labor, and the early postpartum period remained within the range found in normal non pregnant women, and GGT activity was demonstrated in normal placenta. Cord blood had much higher GGT activity than maternal blood. Serum GGT activity is known to increase like that of alkaline phosphatase (ALP) and leucine amino peptidase (LAP) in patients with various liver diseases. Increased serum activity of ALP and LAP in normal prcgnancy compromises the diagnostic usefulness of these enzymes in the gravid state. By contrast, the observation that serum GGT does not change in prcgnancy suggests that it may be of value in the evaluation of intrapartum hepatic and biliary tract disease.

Original languageEnglish (US)
Pages (from-to)745, 749
JournalObstetrics and gynecology
Issue number5
StatePublished - 1974

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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