Abstract
We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation.
Original language | English (US) |
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Pages (from-to) | 12-21 |
Number of pages | 10 |
Journal | JACC: Basic to Translational Science |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2021 |
Keywords
- cardiac fibrosis
- galectin-3
- heart failure
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine