Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations

Ulrike Hoffmann, Jeong Hyun Lee, Tao Qin, Katharina Eikermann-Haerter, Cenk Ayata

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200 mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2 hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression.

Original languageEnglish (US)
Pages (from-to)1578-1582
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number7
StatePublished - Jul 2011
Externally publishedYes


  • gabapentin
  • peri-infarct depolarization
  • spreading depression
  • stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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