Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations

Ulrike Hoffmann; Jeong Hyun Lee; Tao Qin; Katharina Eikermann-Haerter; Cenk Ayata

doi:10.1038/jcbfm.2011.50

Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations

Ulrike Hoffmann, Jeong Hyun Lee, Tao Qin, Katharina Eikermann-Haerter, Cenk Ayata

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200 mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2 hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression.

Original language	English (US)
Pages (from-to)	1578-1582
Number of pages	5
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	31
Issue number	7
DOIs	https://doi.org/10.1038/jcbfm.2011.50
State	Published - Jul 2011
Externally published	Yes

Keywords

gabapentin
peri-infarct depolarization
spreading depression
stroke

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/jcbfm.2011.50

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abstract = "Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200 mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2 hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression.",

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AU - Qin, Tao

AU - Eikermann-Haerter, Katharina

AU - Ayata, Cenk

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Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations

Abstract

Keywords

ASJC Scopus subject areas

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