G Proteins and Regulation of Adenylyl Cyclase

A. G. Gilman

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


The cellular plasma membrane contains highly specialized systems for integration, amplification, and transduction of information that presents itself in the form of extracellular hormones, neurotransmitters, other regulatory molecules, and physical stimuli. A major mechanism for processing this information involves the sequential interactions of three membrane-bound proteins. Receptors for many extracellular regulators bind these molecules and interact with one or more of a family of guanine nucleotide—binding regulatory proteins (G proteins). Conformational alteration of the G protein permits exchange of tightly bound guanosine diphosphate (an inactive ligand) for guanosine triphosphate (the activating ligand). The guanosine triphosphate—bound G protein in turn interacts with intracellular effector molecules, such as adenylyl cyclase, and controls their functions.

Original languageEnglish (US)
Pages (from-to)1819-1825
Number of pages7
JournalJAMA: The Journal of the American Medical Association
Issue number13
StatePublished - Oct 6 1989

ASJC Scopus subject areas

  • Medicine(all)


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