G Proteins and Regulation of Adenylate Cyclase (Nobel Lecture)

Alfred G. Gilman

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


How is the hormone‐activated synthesis of the second messenger cyclic AMP regulated? Or, in more general terms, how does the interaction of an extracellular agonist with a receptor lead to intracellular enzyme activity when receptor and enzyme are not distinct macromolecules? The mediators are membrane‐bound, guanine nucleotide binding regulatory proteins (G proteins). When the receptor is activated, G proteins dissociate into their subunits. These in turn activate or inhibit enzymes such as adenylate cyclases, which catalyze the synthesis of cyclic AMP. In these signal transmission processes G proteins act as molecular switches and amplifiers.

Original languageEnglish (US)
Pages (from-to)1406-1419
Number of pages14
JournalAngewandte Chemie International Edition in English
Issue number13-14
StatePublished - Jul 31 1995


  • G proteins
  • Nobel lecture
  • adenylate cyclases

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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