TY - JOUR
T1 - Fundamental Cardiovascular Research
T2 - Returns on Societal Investment: A Scientific Statement from the American Heart Association
AU - on behalf of the American Heart Association Council on Basic Cardiovascular Sciences; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council on Functional Genomics and Translational Biology; and Stroke Council
AU - Hill, Joseph A
AU - Ardehali, Reza
AU - Clarke, Kimberli T
AU - del Zoppo, Gregory J.
AU - Eckhardt, Lee L.
AU - Griendling, Kathy K.
AU - Libby, Peter
AU - Roden, Dan M.
AU - Sadek, Hesham A
AU - Seidman, Christine E.
AU - Vaughan, Douglas E.
N1 - Publisher Copyright:
© 2017 American Heart Association, Inc.
PY - 2017/7/21
Y1 - 2017/7/21
N2 - Recent decades have witnessed robust successes in conquering the acutely lethal manifestations of heart and vascular diseases. Many patients who previously would have died now survive. Lifesaving successes like these provide a tremendous and easily recognized benefit to individuals and society. Although cardiovascular mortality has declined, the devastating impact of chronic heart disease and comorbidities on quality of life and healthcare resources continues unabated. Future strides, extending those made in recent decades, will require continued research into mechanisms underlying disease prevention, pathogenesis, progression, and therapeutic intervention. However, severe financial constraints currently jeopardize these efforts. To chart a path for the future, this report analyzes the challenges and opportunities we face in continuing the battle against cardiovascular disease and highlights the return on societal investment afforded by fundamental cardiovascular research.
AB - Recent decades have witnessed robust successes in conquering the acutely lethal manifestations of heart and vascular diseases. Many patients who previously would have died now survive. Lifesaving successes like these provide a tremendous and easily recognized benefit to individuals and society. Although cardiovascular mortality has declined, the devastating impact of chronic heart disease and comorbidities on quality of life and healthcare resources continues unabated. Future strides, extending those made in recent decades, will require continued research into mechanisms underlying disease prevention, pathogenesis, progression, and therapeutic intervention. However, severe financial constraints currently jeopardize these efforts. To chart a path for the future, this report analyzes the challenges and opportunities we face in continuing the battle against cardiovascular disease and highlights the return on societal investment afforded by fundamental cardiovascular research.
KW - AHA Scientific Statements
KW - discovery science
KW - drug discovery
KW - heart disease
KW - research (or laboratory research)
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U2 - 10.1161/RES.0000000000000155
DO - 10.1161/RES.0000000000000155
M3 - Article
C2 - 28652256
AN - SCOPUS:85021278551
SN - 0009-7330
VL - 121
SP - e2-e8
JO - Circulation research
JF - Circulation research
IS - 3
ER -