Abstract
Several genes are found on both the human X and Y chromosomes in regions that do not recombine during male meiosis. In each case, nucleotide sequence analysis suggests that these X-Y gene pairs encode similar but nonidentical proteins. Here we show that the human Y- and X-encoded ribosomal proteins, RPS4Y and RPS4X, are interchangeable and provide an essential function: either protein rescued a mutant hamster cell line that was otherwise incapable of growth at modestly elevated temperatures. These findings are consistent with the hypothesis that RPS4 deficiency has a role in Turner syndrome, a complex human phenotype associated with monosomy X.
Original language | English (US) |
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Pages (from-to) | 268-271 |
Number of pages | 4 |
Journal | Nature genetics |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1993 |
ASJC Scopus subject areas
- Genetics