Functional connectivity in the motor cortex of resting human brain using echo‐planar mri

B. Biswal; F. Z. Yetkin; V. M. Haughton; J. S. Hyde

doi:10.1002/mrm.1910340409

Functional connectivity in the motor cortex of resting human brain using echo‐planar mri

B. Biswal, F. Z. Yetkin, V. M. Haughton, J. S. Hyde

Research output: Contribution to journal › Article › peer-review

7617 Scopus citations

Abstract

An MRI time course of 512 echo‐planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (<0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation (P < 10⁻³) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.

Original language	English (US)
Pages (from-to)	537-541
Number of pages	5
Journal	Magnetic resonance in medicine
Volume	34
Issue number	4
DOIs	https://doi.org/10.1002/mrm.1910340409
State	Published - Oct 1995

Keywords

EPI
fMRI
functional connectivity
motor cortex

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1002/mrm.1910340409

Cite this

@article{2838dfaf85944ef0a6356fbf040ca6ef,

title = "Functional connectivity in the motor cortex of resting human brain using echo‐planar mri",

abstract = "An MRI time course of 512 echo‐planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (<0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation (P < 10−3) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.",

keywords = "EPI, fMRI, functional connectivity, motor cortex",

author = "B. Biswal and Yetkin, {F. Z.} and Haughton, {V. M.} and Hyde, {J. S.}",

year = "1995",

month = oct,

doi = "10.1002/mrm.1910340409",

language = "English (US)",

volume = "34",

pages = "537--541",

journal = "Magnetic resonance in medicine",

issn = "0740-3194",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Functional connectivity in the motor cortex of resting human brain using echo‐planar mri

AU - Biswal, B.

AU - Yetkin, F. Z.

AU - Haughton, V. M.

AU - Hyde, J. S.

PY - 1995/10

Y1 - 1995/10

N2 - An MRI time course of 512 echo‐planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (<0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation (P < 10−3) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.

AB - An MRI time course of 512 echo‐planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (<0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation (P < 10−3) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.

KW - EPI

KW - fMRI

KW - functional connectivity

KW - motor cortex

UR - http://www.scopus.com/inward/record.url?scp=0029166541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029166541&partnerID=8YFLogxK

U2 - 10.1002/mrm.1910340409

DO - 10.1002/mrm.1910340409

M3 - Article

C2 - 8524021

AN - SCOPUS:0029166541

SN - 0740-3194

VL - 34

SP - 537

EP - 541

JO - Magnetic resonance in medicine

JF - Magnetic resonance in medicine

IS - 4

ER -

Functional connectivity in the motor cortex of resting human brain using echo‐planar mri

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this