TY - JOUR
T1 - Functional brain networks in never-treated and treated long-term Ill schizophrenia patients
AU - Yao, Li
AU - Li, Fei
AU - Liu, Jieke
AU - Liao, Wei
AU - Li, Xiaojing
AU - Li, Mingli
AU - Meng, Yajing
AU - Liang, Sugai
AU - Zhang, Chengcheng
AU - Yang, Xiao
AU - Wang, Qiang
AU - Ma, Xiaohong
AU - Guo, Wanjun
AU - Sweeney, John A.
AU - Gong, Qiyong
AU - Lui, Su
AU - Deng, Wei
AU - Li, Tao
N1 - Publisher Copyright:
© 2019, American College of Neuropsychopharmacology.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - This study compared the topological organization of brain function in never-treated and treated long-term schizophrenia patients. In a cross-sectional study, 21 never-treated schizophrenia patients with illness duration over 5 years, 26 illness duration-matched antipsychotic-treated patients and 24 demographically-matched healthy controls underwent a resting-state functional magnetic resonance imaging (MRI) scan. The topological properties of brain functional networks were compared across groups, and then we tested for differential age-related effects in regions with significant group differences. Both never-treated and antipsychotic-treated schizophrenia patient groups showed altered nodal centralities in left pre-/postcentral gyri relative to controls. Never-treated patients demonstrated reduced global efficacy, decreased nodal centralities in right amygdala/hippocampus and bilateral putamen/caudate relative to antipsychotic-treated patients and controls. No significant relationships of age and altered functional metrics were seen in either patient group, and no alterations were greater in the treated group. These findings provide insight into brain function deficits over the longer-term course of schizophrenia independent from potential effects of antipsychotic medication. The presence of greater alterations in never-treated than treated patients suggests that long-term antipsychotic treatment may partially protect or enhance brain global and nodal topological function over the course of schizophrenia, notably involving the amygdala, hippocampus, and striatum that have long been associated with the disorder.
AB - This study compared the topological organization of brain function in never-treated and treated long-term schizophrenia patients. In a cross-sectional study, 21 never-treated schizophrenia patients with illness duration over 5 years, 26 illness duration-matched antipsychotic-treated patients and 24 demographically-matched healthy controls underwent a resting-state functional magnetic resonance imaging (MRI) scan. The topological properties of brain functional networks were compared across groups, and then we tested for differential age-related effects in regions with significant group differences. Both never-treated and antipsychotic-treated schizophrenia patient groups showed altered nodal centralities in left pre-/postcentral gyri relative to controls. Never-treated patients demonstrated reduced global efficacy, decreased nodal centralities in right amygdala/hippocampus and bilateral putamen/caudate relative to antipsychotic-treated patients and controls. No significant relationships of age and altered functional metrics were seen in either patient group, and no alterations were greater in the treated group. These findings provide insight into brain function deficits over the longer-term course of schizophrenia independent from potential effects of antipsychotic medication. The presence of greater alterations in never-treated than treated patients suggests that long-term antipsychotic treatment may partially protect or enhance brain global and nodal topological function over the course of schizophrenia, notably involving the amygdala, hippocampus, and striatum that have long been associated with the disorder.
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U2 - 10.1038/s41386-019-0428-2
DO - 10.1038/s41386-019-0428-2
M3 - Article
C2 - 31163450
AN - SCOPUS:85067843709
SN - 0893-133X
VL - 44
SP - 1940
EP - 1947
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 11
ER -