Functional and structural comparison of PXR and CAR

John T. Moore; Linda B. Moore; Jodi M. Maglich; Steve A. Kliewer

doi:10.1016/S0304-4165(02)00481-6

Functional and structural comparison of PXR and CAR

John T. Moore, Linda B. Moore, Jodi M. Maglich, Steve A. Kliewer

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

The nuclear receptors pregnane X receptor (PXR, NR1I2) and constitutive active receptor (CAR, NR1I3) have both been proposed to function as xenosensors, but the details of their respective physiological roles are still being elucidated. We have contrasted these two receptors in a variety of experiments including gene expression assays, cell-based ligand profiling assays, and crystallographic/structural modeling analyses. These data highlight key differences between PXR and CAR.

Original language	English (US)
Pages (from-to)	235-238
Number of pages	4
Journal	Biochimica et Biophysica Acta - General Subjects
Volume	1619
Issue number	3
DOIs	https://doi.org/10.1016/S0304-4165(02)00481-6
State	Published - Feb 17 2003

Keywords

Constitutive active receptor (CAR)
Nuclear receptor
Pregnane X receptor (PXR)
Xenobiotic metabolism

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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10.1016/S0304-4165(02)00481-6

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KW - Nuclear receptor

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KW - Xenobiotic metabolism

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Functional and structural comparison of PXR and CAR

Abstract

Keywords

ASJC Scopus subject areas

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