Functional and structural comparison of PXR and CAR

John T. Moore, Linda B. Moore, Jodi M. Maglich, Steve A. Kliewer

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


The nuclear receptors pregnane X receptor (PXR, NR1I2) and constitutive active receptor (CAR, NR1I3) have both been proposed to function as xenosensors, but the details of their respective physiological roles are still being elucidated. We have contrasted these two receptors in a variety of experiments including gene expression assays, cell-based ligand profiling assays, and crystallographic/structural modeling analyses. These data highlight key differences between PXR and CAR.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalBiochimica et Biophysica Acta - General Subjects
Issue number3
StatePublished - Feb 17 2003


  • Constitutive active receptor (CAR)
  • Nuclear receptor
  • Pregnane X receptor (PXR)
  • Xenobiotic metabolism

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology


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