From stem cells to lymphocytes: Biology and transplantation

Hector L. Aguila; Koichi Akashi; Jos Domen; Kimberly L. Gandy; Eric Lagasse; Reina E. Mebius; Sean J. Morrison; Judy Shizuru; Samuel Strober; Nobuko Uchida; Douglas E. Wright; Irving L. Weissman

doi:10.1111/j.1600-065X.1997.tb00971.x

From stem cells to lymphocytes: Biology and transplantation

Hector L. Aguila, Koichi Akashi, Jos Domen, Kimberly L. Gandy, Eric Lagasse, Reina E. Mebius, Sean J. Morrison, Judy Shizuru, Samuel Strober, Nobuko Uchida, Douglas E. Wright, Irving L. Weissman

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

Original language	English (US)
Pages (from-to)	13-40
Number of pages	28
Journal	Immunological Reviews
Volume	157
DOIs	https://doi.org/10.1111/j.1600-065X.1997.tb00971.x
State	Published - Jan 1 1997

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1111/j.1600-065X.1997.tb00971.x

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title = "From stem cells to lymphocytes: Biology and transplantation",

abstract = "We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.",

author = "Aguila, {Hector L.} and Koichi Akashi and Jos Domen and Gandy, {Kimberly L.} and Eric Lagasse and Mebius, {Reina E.} and Morrison, {Sean J.} and Judy Shizuru and Samuel Strober and Nobuko Uchida and Wright, {Douglas E.} and Weissman, {Irving L.}",

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AU - Aguila, Hector L.

AU - Akashi, Koichi

AU - Domen, Jos

AU - Gandy, Kimberly L.

AU - Lagasse, Eric

AU - Mebius, Reina E.

AU - Morrison, Sean J.

AU - Shizuru, Judy

AU - Strober, Samuel

AU - Uchida, Nobuko

AU - Wright, Douglas E.

AU - Weissman, Irving L.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

AB - We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

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From stem cells to lymphocytes: Biology and transplantation

Abstract

ASJC Scopus subject areas

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