From stem cells to lymphocytes: Biology and transplantation

Hector L. Aguila, Koichi Akashi, Jos Domen, Kimberly L. Gandy, Eric Lagasse, Reina E. Mebius, Sean J. Morrison, Judy Shizuru, Samuel Strober, Nobuko Uchida, Douglas E. Wright, Irving L. Weissman

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations


We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

Original languageEnglish (US)
Pages (from-to)13-40
Number of pages28
JournalImmunological Reviews
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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