From medications to surgery: Advances in the treatment of motor complications in Parkinson's disease

Kanae Jennifer Nagao; Neepa J. Patel

doi:10.7573/dic.212592

From medications to surgery: Advances in the treatment of motor complications in Parkinson's disease

Kanae Jennifer Nagao, Neepa J. Patel

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fuctuations and dyskinesia.

Original language	English (US)
Article number	212592
Journal	Drugs in Context
Volume	8
DOIs	https://doi.org/10.7573/dic.212592
State	Published - 2019
Externally published	Yes

Keywords

Deep brain stimulation
Levodopa
Parkinson's disease
Therapy

ASJC Scopus subject areas

Pharmacology

Access to Document

10.7573/dic.212592

Cite this

@article{907fbee808554573a904542de262a65a,

title = "From medications to surgery: Advances in the treatment of motor complications in Parkinson's disease",

abstract = "Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fuctuations and dyskinesia.",

keywords = "Deep brain stimulation, Levodopa, Parkinson's disease, Therapy",

author = "Nagao, {Kanae Jennifer} and Patel, {Neepa J.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 Nagao KJ, Patel NJ.",

year = "2019",

doi = "10.7573/dic.212592",

language = "English (US)",

volume = "8",

journal = "Drugs in Context",

issn = "1745-1981",

publisher = "JUST Medical Media Limited",

}

TY - JOUR

T1 - From medications to surgery

T2 - Advances in the treatment of motor complications in Parkinson's disease

AU - Nagao, Kanae Jennifer

AU - Patel, Neepa J.

PY - 2019

Y1 - 2019

N2 - Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fuctuations and dyskinesia.

AB - Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson's disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fuctuations and dyskinesia.

KW - Deep brain stimulation

KW - Levodopa

KW - Parkinson's disease

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=85075739128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075739128&partnerID=8YFLogxK

U2 - 10.7573/dic.212592

DO - 10.7573/dic.212592

M3 - Review article

C2 - 31516532

AN - SCOPUS:85075739128

SN - 1745-1981

VL - 8

JO - Drugs in Context

JF - Drugs in Context

M1 - 212592

ER -

From medications to surgery: Advances in the treatment of motor complications in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this