@inproceedings{c6b42bbd7b1544998acdc94077a627f9,
title = "FRET-like fluorophore-nanoparticle complex for highly specific cancer localization",
abstract = "Fluorophore mediated bio-signal retrieval has been extensively used in molecular imaging. However, only a limited number of fluorophores can be used for humans and their quantum yield is usually low. Another important issue is emitting fluorescence at the disease site, with a minimal non-specific emission at any other sites. Artificial quenching and enhancing of fluorescence was found to be possible by manipulating the distance between a fluorophore and a certain type of nanometal particle. Utilizing this unique property, we have designed a novel, FRET-like, fluorophore-nanoparticle complex. The complex emits fluorescence conditionally only at a disease site at an enhanced level. As a model system, our complex is designed to target breast cancer. As an initial step for developing this cancer locator, fluorescence alteration was studied when a spacer at various lengths is placed between a nanogold particle and a safe fluorophore.",
author = "Jianting Wang and Nantz, {Michael H.} and Samuel Achilefu and Kang, {Kyung A.}",
note = "Funding Information: Authors acknowledge U.S. Army (DoD) Breast Cancer Program (BC074387) for the financial support.",
year = "2010",
doi = "10.1007/978-1-4419-1241-1_59",
language = "English (US)",
isbn = "9781441912398",
series = "Advances in Experimental Medicine and Biology",
pages = "407--413",
editor = "Eiji Takahashi and Duane Bruley",
booktitle = "Oxygen Transport to Tissue XXXI",
}