Frequency domain tomography in small animals with the equation of radiative transfer

Kui Ren; Bryte Moa-Anderson; Guillaume Bal; Xuejun Gu; Andreas H. Hielscher

doi:10.1117/12.591113

Frequency domain tomography in small animals with the equation of radiative transfer

Kui Ren, Bryte Moa-Anderson, Guillaume Bal, Xuejun Gu, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Scopus citations

Abstract

We have developed a model-based iterative image reconstruction scheme based on the equation of radiative transfer in the frequency domain for the applications in small animal optical tomographic imaging. To test the utility of such a code in small animal imaging we have furthermore developed a numerical phantom of a mouse. In simulation studies using this and other phantoms, we found that to make truly use of phase information in the reconstruction process modulation frequencies well above 100 MHz are necessary. Only at these higher frequencies the phase shifts introduced by the lesions of interest are large enough to be measured. For smaller frequencies no substantial improvements over steady-state systems are achieved in small geometries typical for small animal imaging.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Editors	B. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca
Pages	111-120
Number of pages	10
Volume	5693
DOIs	https://doi.org/10.1117/12.591113
State	Published - 2005
Event	Optical Tomography and Spectroscopy of Tissue VI - San Jose, CA, United States Duration: Jan 23 2005 → Jan 26 2005

Other

Other	Optical Tomography and Spectroscopy of Tissue VI
Country/Territory	United States
City	San Jose, CA
Period	1/23/05 → 1/26/05

Keywords

Discrete ordinate
Equation of radiative transfer
Finite volume method
Inverse problems
Optical tomography
Small animal imaging

ASJC Scopus subject areas

Engineering(all)

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10.1117/12.591113

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Ren, K., Moa-Anderson, B., Bal, G., Gu, X., & Hielscher, A. H. (2005). Frequency domain tomography in small animals with the equation of radiative transfer. In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraca (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5693, pp. 111-120). Article 22 https://doi.org/10.1117/12.591113

Frequency domain tomography in small animals with the equation of radiative transfer. / Ren, Kui; Moa-Anderson, Bryte; Bal, Guillaume et al.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / B. Chance; R.R. Alfano; B.J. Tromberg; M. Tamura; E.M. Sevick-Muraca. Vol. 5693 2005. p. 111-120 22.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ren, K, Moa-Anderson, B, Bal, G, Gu, X & Hielscher, AH 2005, Frequency domain tomography in small animals with the equation of radiative transfer. in B Chance, RR Alfano, BJ Tromberg, M Tamura & EM Sevick-Muraca (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5693, 22, pp. 111-120, Optical Tomography and Spectroscopy of Tissue VI, San Jose, CA, United States, 1/23/05. https://doi.org/10.1117/12.591113

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Frequency domain tomography in small animals with the equation of radiative transfer

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