Fragmentation and unpredictability of early-life experience in mental disorders

Tallie Z. Baram, Elysia P. Davis, Andre Obenaus, Curt A. Sandman, Steven L. Small, Ana Solodkin, Hal Stern

Research output: Contribution to journalReview articlepeer-review

181 Scopus citations


Maternal sensory signals in early life play a crucial role in programming the structure and function of the developing brain, promoting vulnerability or resilience to emotional and cognitive disorders. In rodent models of early-life stress, fragmentation and unpredictability of maternally derived sensory signals provoke persistent cognitive and emotional dysfunction in offspring. Similar variability and inconsistency of maternal signals during both gestation and early postnatal human life may influence development of emotional and cognitive functions, including those that underlie later depression and anxiety.

Original languageEnglish (US)
Pages (from-to)907-915
Number of pages9
JournalAmerican Journal of Psychiatry
Issue number9
StatePublished - Aug 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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