Folate receptor imaging with 125I labeled folic acid with a whole body small animal imaging device built with plastic scintillating optical fibers

P. V. Kulkarni; P. P. Antich; A. Constantinescu; J. Prior; T. Nguyen; J. Fernando; J. A. Anderson; S. D. Weitman; B. A. Kamen; R. W. Parkey; R. C. Chaney; E. J. Fenyves

doi:10.1016/0168-583X(95)00220-0

Folate receptor imaging with ¹²⁵I labeled folic acid with a whole body small animal imaging device built with plastic scintillating optical fibers

P. V. Kulkarni, P. P. Antich, A. Constantinescu, J. Prior, T. Nguyen, J. Fernando, J. A. Anderson, S. D. Weitman, B. A. Kamen, R. W. Parkey, R. C. Chaney, E. J. Fenyves

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A small animal whole body imaging cylindrical device was built with plastic scintillating fibers and position sensitive photomultipliers (Hamamatsu) and digitized using flash ADCs. A co-axial brass mesh collimator (septum thickness 1 mm) was used in combination with an electronic collimation scheme to enhance spatial resolution. Imaging studies with ¹²⁵I labeled folic acid were performed in mice bearing folate receptor +ve (IGROV) tumor and receptor -ve (Meth-A) tumor. In-situ imaging of animals sacrificed at 15-30 min post injection of the tracer showed the localization of the tumor in animals with the folate receptor +ve tumors. Our initial studies demonstrate the utility of a device built with plastic scintillating fibers in small animal imaging studies with low energy photons (25-35 keV).

Original language	English (US)
Pages (from-to)	800-803
Number of pages	4
Journal	Nuclear Inst. and Methods in Physics Research, B
Volume	99
Issue number	1-4
DOIs	https://doi.org/10.1016/0168-583X(95)00220-0
State	Published - May 5 1995

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

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10.1016/0168-583X(95)00220-0

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Kulkarni, P. V., Antich, P. P., Constantinescu, A., Prior, J., Nguyen, T., Fernando, J., Anderson, J. A., Weitman, S. D., Kamen, B. A., Parkey, R. W., Chaney, R. C., & Fenyves, E. J. (1995). Folate receptor imaging with ¹²⁵I labeled folic acid with a whole body small animal imaging device built with plastic scintillating optical fibers. Nuclear Inst. and Methods in Physics Research, B, 99(1-4), 800-803. https://doi.org/10.1016/0168-583X(95)00220-0

Folate receptor imaging with ¹²⁵I labeled folic acid with a whole body small animal imaging device built with plastic scintillating optical fibers. / Kulkarni, P. V.; Antich, P. P.; Constantinescu, A. et al.
In: Nuclear Inst. and Methods in Physics Research, B, Vol. 99, No. 1-4, 05.05.1995, p. 800-803.

Research output: Contribution to journal › Article › peer-review

Kulkarni, PV, Antich, PP, Constantinescu, A, Prior, J, Nguyen, T, Fernando, J, Anderson, JA, Weitman, SD, Kamen, BA, Parkey, RW, Chaney, RC & Fenyves, EJ 1995, 'Folate receptor imaging with ¹²⁵I labeled folic acid with a whole body small animal imaging device built with plastic scintillating optical fibers', Nuclear Inst. and Methods in Physics Research, B, vol. 99, no. 1-4, pp. 800-803. https://doi.org/10.1016/0168-583X(95)00220-0

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title = "Folate receptor imaging with 125I labeled folic acid with a whole body small animal imaging device built with plastic scintillating optical fibers",

abstract = "A small animal whole body imaging cylindrical device was built with plastic scintillating fibers and position sensitive photomultipliers (Hamamatsu) and digitized using flash ADCs. A co-axial brass mesh collimator (septum thickness 1 mm) was used in combination with an electronic collimation scheme to enhance spatial resolution. Imaging studies with 125I labeled folic acid were performed in mice bearing folate receptor +ve (IGROV) tumor and receptor -ve (Meth-A) tumor. In-situ imaging of animals sacrificed at 15-30 min post injection of the tracer showed the localization of the tumor in animals with the folate receptor +ve tumors. Our initial studies demonstrate the utility of a device built with plastic scintillating fibers in small animal imaging studies with low energy photons (25-35 keV).",

author = "Kulkarni, {P. V.} and Antich, {P. P.} and A. Constantinescu and J. Prior and T. Nguyen and J. Fernando and Anderson, {J. A.} and Weitman, {S. D.} and Kamen, {B. A.} and Parkey, {R. W.} and Chaney, {R. C.} and Fenyves, {E. J.}",

note = "Funding Information: Work supported in part by Texas Higher Education Co-Ordinating Board (Project # 003060-078).F olic acid monohistamine conjugate was Joseph Shih at Eli Lily Co.",

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doi = "10.1016/0168-583X(95)00220-0",

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AU - Fenyves, E. J.

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Folate receptor imaging with ¹²⁵I labeled folic acid with a whole body small animal imaging device built with plastic scintillating optical fibers

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