TY - JOUR
T1 - Fluid-Filled Versus Gas-Filled Intragastric Balloons as Obesity Interventions
T2 - a Network Meta-analysis of Randomized Trials
AU - Bazerbachi, Fateh
AU - Haffar, Samir
AU - Sawas, Tarek
AU - Vargas, Eric J.
AU - Kaur, Ravinder Jeet
AU - Wang, Zhen
AU - Prokop, Larry J.
AU - Murad, M. Hassan
AU - Abu Dayyeh, Barham K.
N1 - Funding Information:
Fateh Bazerbachi: none, Samir Haffar: none, Tarek Sawas: none, Eric J. Vargas: none, Ravinder Jeet Kaur: none, Zhen Wang: none, Larry Prokop: none, M. Hassan Murad: none, Barham K. Abu Dayyeh received research grants by Spatz Medical and Apollo Endosurgery.
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Background: Four commercially available intragastric balloons have been used for the management of obesity and underwent randomized controlled trials (RCTs), and we aimed to compare them using a network meta-analysis approach. Methods: Several databases were queried from inception to May 26, 2017, and we included RCTs enrolling patients treated with Orbera, Heliosphere, ReShape Duo, and Obalon compared with another balloon, sham, or open-label control group. Two investigators independently abstracted data. A random effects frequentist network meta-analysis and relative ranking of agents using surface under the cumulative ranking probabilities were performed. Results: We included 15 trials at low risk of bias (only two were head-to-head). Compared to control groups, the two fluid-filled devices were associated with significant outcome (% total body weight loss) at 6 months: Orbera, 6.72% (95% CI, 5.55, 7.89) and ReShape Duo 4% (95% CI 2.69, 5.31). Only one of the two gas-filled devices was associated with significant outcome at 6 months: Obalon 3.3% (95% CI 2.30, 4.30), and not the second: Heliosphere 6.71% (95% CI − 0.82, 14.23). Fluid-filled devices had the highest likelihood of superiority in achieving the outcome at 6 months (96.8%) and at 12 months (96.6%). The quality of evidence was high for comparisons against control. Conclusions: Fluid-filled balloons are more likely to produce weight loss compared to gas-filled balloons or lifestyle intervention. However, they may be associated with a higher rate of intolerance and early removal. This information will aid clinicians in device selection and engaging patients in shared decision-making.
AB - Background: Four commercially available intragastric balloons have been used for the management of obesity and underwent randomized controlled trials (RCTs), and we aimed to compare them using a network meta-analysis approach. Methods: Several databases were queried from inception to May 26, 2017, and we included RCTs enrolling patients treated with Orbera, Heliosphere, ReShape Duo, and Obalon compared with another balloon, sham, or open-label control group. Two investigators independently abstracted data. A random effects frequentist network meta-analysis and relative ranking of agents using surface under the cumulative ranking probabilities were performed. Results: We included 15 trials at low risk of bias (only two were head-to-head). Compared to control groups, the two fluid-filled devices were associated with significant outcome (% total body weight loss) at 6 months: Orbera, 6.72% (95% CI, 5.55, 7.89) and ReShape Duo 4% (95% CI 2.69, 5.31). Only one of the two gas-filled devices was associated with significant outcome at 6 months: Obalon 3.3% (95% CI 2.30, 4.30), and not the second: Heliosphere 6.71% (95% CI − 0.82, 14.23). Fluid-filled devices had the highest likelihood of superiority in achieving the outcome at 6 months (96.8%) and at 12 months (96.6%). The quality of evidence was high for comparisons against control. Conclusions: Fluid-filled balloons are more likely to produce weight loss compared to gas-filled balloons or lifestyle intervention. However, they may be associated with a higher rate of intolerance and early removal. This information will aid clinicians in device selection and engaging patients in shared decision-making.
KW - Bariatric endoscopic therapies
KW - Therapeutic endoscopy
KW - Weight loss
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U2 - 10.1007/s11695-018-3227-7
DO - 10.1007/s11695-018-3227-7
M3 - Article
C2 - 29663250
AN - SCOPUS:85045449673
SN - 0960-8923
VL - 28
SP - 2617
EP - 2625
JO - Obesity Surgery
JF - Obesity Surgery
IS - 9
ER -