Abstract
Caveolae are plasmalemmal microdomains that are involved in vesicular trafficking and signal transduction. We have sought to identify novel integral membrane proteins of caveolae. Here we describe the identification and molecular cloning of flotillin. By several independent methods, flotillin behaves as a resident integral membrane protein component of caveolae. Furthermore, we have identified epidermal surface antigen both as a flotillin homologue and as a resident caveolar protein. Significantly, flotillin is a marker for the Triton-insoluble, buoyant membrane fraction in brain, where to date mRNA species for known caveolin gene family members have not been detected.
Original language | English (US) |
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Pages (from-to) | 13793-13802 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 272 |
Issue number | 21 |
DOIs | |
State | Published - May 23 1997 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology