Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice

M. Sri Balasubashini; S. Karthigayan; S. T. Somasundaram; T. Balasubramanian; V. Viswanathan; P. Raveendran; V. P. Menon

doi:10.1016/j.bmcl.2006.09.025

Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice

M. Sri Balasubashini, S. Karthigayan, S. T. Somasundaram, T. Balasubramanian, V. Viswanathan, P. Raveendran, V. P. Menon

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The present study was carried out to assess the effect of Pterios volitans venom (mixture of peptides) on Ehrlich's ascites carcinoma (EAC) and its influence on antioxidant status in the liver. Among six groups of albino mice, three were treated with sublethal doses of venom, along with the standard drug, 5-fluorouracil. In EAC-bearing mice, mean life span and antioxidants were significantly decreased, whereas, body weight, tumor volume, viable tumor cell count, lipid peroxidation and expression of proliferating cell nuclear antigen were significantly increased. These changes were brought back to near normal in treatment groups. The findings are further confirmed by histopathological observations.

Original language	English (US)
Pages (from-to)	6219-6225
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2006.09.025
State	Published - Dec 15 2006

Keywords

Fish venom
PCNA
Tumor metastasis

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2006.09.025

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Sri Balasubashini, M., Karthigayan, S., Somasundaram, S. T., Balasubramanian, T., Viswanathan, V., Raveendran, P., & Menon, V. P. (2006). Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice. Bioorganic and Medicinal Chemistry Letters, 16(24), 6219-6225. https://doi.org/10.1016/j.bmcl.2006.09.025

Sri Balasubashini, M, Karthigayan, S, Somasundaram, ST, Balasubramanian, T, Viswanathan, V, Raveendran, P & Menon, VP 2006, 'Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice', Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 24, pp. 6219-6225. https://doi.org/10.1016/j.bmcl.2006.09.025

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abstract = "The present study was carried out to assess the effect of Pterios volitans venom (mixture of peptides) on Ehrlich's ascites carcinoma (EAC) and its influence on antioxidant status in the liver. Among six groups of albino mice, three were treated with sublethal doses of venom, along with the standard drug, 5-fluorouracil. In EAC-bearing mice, mean life span and antioxidants were significantly decreased, whereas, body weight, tumor volume, viable tumor cell count, lipid peroxidation and expression of proliferating cell nuclear antigen were significantly increased. These changes were brought back to near normal in treatment groups. The findings are further confirmed by histopathological observations.",

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AU - Somasundaram, S. T.

AU - Balasubramanian, T.

AU - Viswanathan, V.

AU - Raveendran, P.

AU - Menon, V. P.

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AB - The present study was carried out to assess the effect of Pterios volitans venom (mixture of peptides) on Ehrlich's ascites carcinoma (EAC) and its influence on antioxidant status in the liver. Among six groups of albino mice, three were treated with sublethal doses of venom, along with the standard drug, 5-fluorouracil. In EAC-bearing mice, mean life span and antioxidants were significantly decreased, whereas, body weight, tumor volume, viable tumor cell count, lipid peroxidation and expression of proliferating cell nuclear antigen were significantly increased. These changes were brought back to near normal in treatment groups. The findings are further confirmed by histopathological observations.

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Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice

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Keywords

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