TY - JOUR
T1 - Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice
AU - Sri Balasubashini, M.
AU - Karthigayan, S.
AU - Somasundaram, S. T.
AU - Balasubramanian, T.
AU - Viswanathan, V.
AU - Raveendran, P.
AU - Menon, V. P.
PY - 2006/12/15
Y1 - 2006/12/15
N2 - The present study was carried out to assess the effect of Pterios volitans venom (mixture of peptides) on Ehrlich's ascites carcinoma (EAC) and its influence on antioxidant status in the liver. Among six groups of albino mice, three were treated with sublethal doses of venom, along with the standard drug, 5-fluorouracil. In EAC-bearing mice, mean life span and antioxidants were significantly decreased, whereas, body weight, tumor volume, viable tumor cell count, lipid peroxidation and expression of proliferating cell nuclear antigen were significantly increased. These changes were brought back to near normal in treatment groups. The findings are further confirmed by histopathological observations.
AB - The present study was carried out to assess the effect of Pterios volitans venom (mixture of peptides) on Ehrlich's ascites carcinoma (EAC) and its influence on antioxidant status in the liver. Among six groups of albino mice, three were treated with sublethal doses of venom, along with the standard drug, 5-fluorouracil. In EAC-bearing mice, mean life span and antioxidants were significantly decreased, whereas, body weight, tumor volume, viable tumor cell count, lipid peroxidation and expression of proliferating cell nuclear antigen were significantly increased. These changes were brought back to near normal in treatment groups. The findings are further confirmed by histopathological observations.
KW - Fish venom
KW - PCNA
KW - Tumor metastasis
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U2 - 10.1016/j.bmcl.2006.09.025
DO - 10.1016/j.bmcl.2006.09.025
M3 - Article
C2 - 17000104
AN - SCOPUS:33750820709
SN - 0960-894X
VL - 16
SP - 6219
EP - 6225
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 24
ER -