Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading

Research output: Contribution to journalArticlepeer-review

345 Scopus citations


Fibroblast-collagen-matrix contraction provides a unique way to study reciprocal geometric and mechanical interactions between fibroblasts and extracellular matrix. Such interactions are difficult to appreciate or examine in routine cell culture because the culture surface is usually fixed in place. Forces exerted on collagen fibrils by cells cause isometric tension to develop in the cells if the collagen resists deformation; by contrast, the cells remain mechanically unloaded in the absence of matrix resistance. Recent evidence suggests that the state of cellular mechanical loading determines the mechanism that cells use to regulate contraction. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalTrends in Cell Biology
Issue number9
StatePublished - Sep 1 2000

ASJC Scopus subject areas

  • Cell Biology


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