Fertility in patients with congenital adrenal hyperplasia

David E. Reichman, Perrin C. White, Maria I. New, Zev Rosenwaks

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


Congenital adrenal hyperplasia (CAH) is the most frequently encountered genetic steroid disorder affecting fertility. Steroid hormones play a crucial role in sexual development and reproductive function; patients with either 21- hydroxylase or 11β-hydroxylase deficiency thus face immense challenges to their fertility. Given the relevance of CAH in reproductive medicine as well as the diagnostic challenges posed by the phenotypic overlap with polycystic ovary syndrome, we review the reproductive pahophysiology of both classic and nonclassic CAH and present contemporary treatment options.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalFertility and sterility
Issue number2
StatePublished - Feb 2014


  • 11b-hydroxylase
  • 21 hydroxylase
  • CAH
  • genotype
  • infertility
  • phenotype
  • steroidogenesis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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