Fertility in patients with congenital adrenal hyperplasia

David E. Reichman; Perrin C. White; Maria I. New; Zev Rosenwaks

doi:10.1016/j.fertnstert.2013.11.002

Fertility in patients with congenital adrenal hyperplasia

David E. Reichman, Perrin C. White, Maria I. New, Zev Rosenwaks

Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

Abstract

Congenital adrenal hyperplasia (CAH) is the most frequently encountered genetic steroid disorder affecting fertility. Steroid hormones play a crucial role in sexual development and reproductive function; patients with either 21- hydroxylase or 11β-hydroxylase deficiency thus face immense challenges to their fertility. Given the relevance of CAH in reproductive medicine as well as the diagnostic challenges posed by the phenotypic overlap with polycystic ovary syndrome, we review the reproductive pahophysiology of both classic and nonclassic CAH and present contemporary treatment options.

Original language	English (US)
Pages (from-to)	301-309
Number of pages	9
Journal	Fertility and sterility
Volume	101
Issue number	2
DOIs	https://doi.org/10.1016/j.fertnstert.2013.11.002
State	Published - Feb 2014

Keywords

11b-hydroxylase
21 hydroxylase
CAH
genotype
infertility
phenotype
steroidogenesis

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2013.11.002

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title = "Fertility in patients with congenital adrenal hyperplasia",

abstract = "Congenital adrenal hyperplasia (CAH) is the most frequently encountered genetic steroid disorder affecting fertility. Steroid hormones play a crucial role in sexual development and reproductive function; patients with either 21- hydroxylase or 11β-hydroxylase deficiency thus face immense challenges to their fertility. Given the relevance of CAH in reproductive medicine as well as the diagnostic challenges posed by the phenotypic overlap with polycystic ovary syndrome, we review the reproductive pahophysiology of both classic and nonclassic CAH and present contemporary treatment options.",

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AU - White, Perrin C.

AU - New, Maria I.

AU - Rosenwaks, Zev

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AB - Congenital adrenal hyperplasia (CAH) is the most frequently encountered genetic steroid disorder affecting fertility. Steroid hormones play a crucial role in sexual development and reproductive function; patients with either 21- hydroxylase or 11β-hydroxylase deficiency thus face immense challenges to their fertility. Given the relevance of CAH in reproductive medicine as well as the diagnostic challenges posed by the phenotypic overlap with polycystic ovary syndrome, we review the reproductive pahophysiology of both classic and nonclassic CAH and present contemporary treatment options.

KW - 11b-hydroxylase

KW - 21 hydroxylase

KW - CAH

KW - genotype

KW - infertility

KW - phenotype

KW - steroidogenesis

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Fertility in patients with congenital adrenal hyperplasia

Abstract

Keywords

ASJC Scopus subject areas

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