@article{fb91d332cbed44259635849ee1ec6e39,
title = "Ferroptosis in infection, inflammation, and immunity",
abstract = "Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death is implicated in a growing list of physiological and pathophysiological processes, coupled to a dysregulated immune response. This review focuses on new discoveries related to how ferroptotic cells and their spilled contents shape innate and adaptive immunity in health and disease. Understanding the immunological characteristics and activity of ferroptotic death not only illuminates an intersection between cell death and immunity but may also lead to the development of novel treatment approaches for immunopathological diseases.",
author = "Xin Chen and Rui Kang and Guido Kroemer and Daolin Tang",
note = "Funding Information: G. Kroemer is supported by the Agence Nationale de la Recherche–Projets blancs; Agence Nationale de la Recherche under the frame of the ERA-Net for Research on Rare Diseases (E-Rare-2); Association pour la Recherche sur le Cancer; Canc{\'e}rop{\^o}le Ile de France; Chancellerie des Universit{\'e}s de Paris (Legs Poix); a donation by Elior; European Research Area Network on Cardiovascular Diseases (MINOTAUR); Fonda-tion Carrefour; Fondation pour la Recherche M{\'e}dicale; Gustave Roussy Odyssea; the European Union Horizon 2020 Framework Programme Project Oncobiome; High-end Foreign Expert Program in China (GDW20171100085 and GDW20181100051); Institut National de la Sant{\'e}et de la Recherche M{\'e}dicale (Heterogeneity of Tumors & Ecosystem); Institut National du Cancer; Institut Universitaire de France; LabEx Immuno-Oncology; LeDucq Foundation; Ligue Contre le Cancer ({\'e}quipe labellis{\'e}e); Recherche Hospitalo-Universitaire Torino Lumi{\`e}re; Seerave Foundation; SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination; and SIRIC Cancer Research and Personalized Medicine. Publisher Copyright: {\textcopyright} 2021 Rockefeller University Press. All rights reserved.",
year = "2021",
month = may,
day = "12",
doi = "10.1084/jem.20210518",
language = "English (US)",
volume = "218",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "6",
}